Results 231 to 240 of about 53,254,105 (402)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Toxicity assessments of chemical substances using primary culture of rat hepatocytes.

, 1986
Jin Fang, Yasuhisa Kitagawa, Shinsuke Ishikawa, Hiroyuki Yanagisawa, Katsuyuki Nakajima, Shigeo Manabe, Osamu Wada   +6 more
openalex   +2 more sources

Influence of Parent–Youth Relationship, Parental Monitoring, and Parent Substance Use on Adolescent Substance Use Onset

Journal of family psychology, 2018
Julie C. Rusby, J. Light, Ryann Crowley, E. Westling   +3 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

A760 PATIENTS WITH A SUBSTANCE ABUSE HISTORY CAN EFFECTIVELY USE PCA [PDF]

, 1990
Brett R. Stacey, Michael C. Brody, DR Burke   +2 more
openalex   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Changes in the trajectories of drug-free friendships and substance use among a cohort of individuals with multiple substance use disorders. [PDF]

Nordisk Alkohol Nark
Moe FD, Tjora T, Moltu C, McKay JR, Hagen E, Erga A, Bjornestad J.   +6 more
europepmc   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

The BioSUD Biobank as a genomic resource for substance use disorders in Italy. [PDF]

Sci Rep
Ribatti RM, de Gennaro L, Daponte A, Cozzoli D, Quaranta MR, Ostuni A, Casanova M, Ariano V, Leone V, Perrone F, Bona SD, Lacalamita A, De Fazio S, Lorusso D, Metspalu M, Torroni A, Olivieri A, Capelli C, Antonacci F, Catacchio CR, Ventura M, Montinaro F.   +21 more
europepmc   +1 more source

Separation of fine biochemical substances using supercritical CO2 extraction.

, 1988
Masayoshi Kubota, Harumi Matsuzaki, Sankichi Takahashi   +2 more
openalex   +2 more sources