Results 231 to 240 of about 54,698,481 (374)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The conception of the ABCD study: From substance use to a broad NIH collaboration

Developmental Cognitive Neuroscience, 2017
N. Volkow, G. Koob, R. Croyle, D. Bianchi, J. Gordon, W. Koroshetz, E. Perez-stable, W. Riley, M. Bloch, K. Conway, B. Deeds, G. Dowling, S. Grant, K. Howlett, J. Matochik, Glen D. Morgan, M. Murray, A. Noronha, C. Spong, Eric M. Wargo, K. Warren, S. Weiss   +21 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity. [PDF]

Addict Biol
Schwarz K, Hildebrandt MK, Sauer N, Wüllhorst R, Endrass T.   +4 more
europepmc   +1 more source

Examination of the Relationship between Trauma Exposure and Substance Use Severity in Pregnant and Recently Pregnant Opioid Users

, 2016
Jennifer A. Coleman
openalex   +1 more source

Is moral adequacy possible in the face of structural disadvantage? The experiences of health and social care staff in supporting homeless people using substances at the end of life

Gary Witham, Gemma Anne Yarwood, Sarah Galvani, Lucy Webb, Sam Wright   +4 more
openalex   +1 more source

Stigma and Discrimination in Families in Mexico with Substance Use: An Intersectionality-Based Approach [PDF]

Jazmín Mora-Ríos, Adán Aranda Reynoso, Victor Daniel Vaugier Mora   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Substance use agreements: An exploratory study of dyadic coping processes related to substance use among male couples in the US. [PDF]

Couple Family Psychol
Starks TJ, Cain D.
europepmc   +1 more source