Results 271 to 280 of about 2,260,368 (324)

Prevalence and correlates of substance use among middle and high school students in Settat Province, Morocco. [PDF]

Subst Abuse Treat Prev Policy
El Moubchiri C, Chahboune M, Guennouni M, Hilali A.   +3 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Socioeconomic inequalities, substance use, and chronic multimorbidity in Kiambu and Nakuru counties in Kenya. [PDF]

PLOS Glob Public Health
Ongeri L, Kaduka L, Matoke D, Njomo D, Bukania Z, Mwangi M, Ndegwa L, Olale J, Othieno C, Hussein S, Barini G, Wanga V, Mogeni P.   +12 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Childhood trauma and adolescent substance use: an integrative perspective. [PDF]

Future Sci OA
Hoffmann JP, Hoffmann CS.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Relapse risk, frustration tolerance, and motivational readiness for change in substance use disorders. [PDF]

BMC Psychol
Zaher A, Mourad G, Ibrahim F.
europepmc   +1 more source

Ketamine's Therapeutic Role in Substance Use Disorders: A Narrative Review. [PDF]

NeuroSci
Thomas A, Chambers RA.
europepmc   +1 more source