Results 61 to 70 of about 53,254,105 (402)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Injecting drugs alone during an overdose crisis in Vancouver, Canada
Harm Reduction Journal, 2022 Background Settings throughout Canada and the USA continue to experience crises of overdose death due to the toxic unregulated drug supply. Injecting drugs alone limits the potential for intervention and has accounted for a significant proportion of ...
Alexa Norton +5 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Use of withdrawal management services among people who use illicit drugs in Vancouver, Canada
Substance Abuse Treatment, Prevention, and Policy, 2018 Background For many individuals with substance use disorders, the entry point for addiction treatment can be through withdrawal management (e.g. detoxification) services.
Sharon Vipler +6 more
doaj +1 more source
Stimulant safe supply: a potential opportunity to respond to the overdose epidemic
Harm Reduction Journal, 2020 Background Occurring against the backdrop of an overdose crisis, stimulant use and stimulant-involved deaths in North America are increasing at an alarming rate.
Taylor Fleming +4 more
doaj +1 more source
BMC Public Health, 2020 Background As research on HIV vaccines continues to advance, studies exploring the feasibility of this intervention are necessary to inform uptake and dissemination strategies with key populations, including people who use drugs (PWUD).
Taylor Fleming +5 more
doaj +1 more source
Doing community-based research during dual public health emergencies (COVID and overdose)
Harm Reduction Journal, 2023 Meaningful engagement and partnerships with people who use drugs are essential to conducting research that is relevant and impactful in supporting desired outcomes of drug consumption as well as reducing drug-related harms of overdose and COVID-19 ...
Phoenix Beck McGreevy +16 more
doaj +1 more source
The Adolescent Substance Use Risk Continuum: A Cultural, Strengths-Based Approach to Case Conceptualization [PDF]
, 2017 Many theories are used to conceptualize adolescent substance use, yet none adequately assist mental health professionals in assessing adolescents’ strengths and risk factors while incorporating cultural factors.
Cook, Jennifer, Miller, Alexis
core +1 more source
Substance use risk profiles and associations with early substance use in adolescence [PDF]
Journal of Behavioral Medicine, 2010 We examined whether anxiety sensitivity, hopelessness, sensation seeking, and impulsivity (i.e., revised version of the Substance Use Risk Profile Scale) would be related to the lifetime prevalence and age of onset of alcohol, tobacco, and cannabis use, and to polydrug use in early adolescence.
Malmberg, M. +5 more
openaire +4 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source