Results 141 to 150 of about 639,012 (296)

Substance use disorder (SUD) among anesthesiologists

Brazilian Journal of Anesthesiology, 2021
Guilherme Antonio Moreira de Barros, Gastão F. Duval Neto   +1 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Parental Parenting Styles in Patients with Substance Use Disorders: A Study in Songkhla, Thailand

Journal of Health Science and Medical Research (JHSMR), 2016
Objective: To evaluate the association between drug use and perceived parenting styles among patients with substance use disorders. Material and Methods: This cross-sectional study enrolled patients aged above 18 years, who received services at Thanyarak
Jaturaporn Sangkool, Chonnakarn Jatchavala   +1 more
doaj  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Delusional Disorder

, 1999
Excerpt: Delusional disorder is one among several types of psychotic disorders, all of which involve grossly impaired reality testing. The core feature of delusional disorder is one or more nonbizarre delusions that last for at least one month.
Thurston, Nancy S.
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Patients' Perceptions of the Role of Nursing in Substance Use Disorder Treatment Programs: Qualitative Study. [PDF]

JMIR Nurs
Lucas Guerra C, Gómez de Quero Córdoba M, García Tardón B, González Naranjo G, Mayoral Gonzalo N.   +4 more
europepmc   +1 more source

Distinguishing Between Substance Use and Substance Use Disorder [PDF]

JAMA Internal Medicine, 2015
openaire   +2 more sources