Results 131 to 140 of about 271,425 (315)

Serum irisin and caspase-9 levels in adolescents with substance use disorder: a case-control study [PDF]

Background: During adolescence, individuals experience rapid changes in physical, cognitive, emotional, behavioral, and social aspects of their life.
Can, Ummugulsum, Usta, Zeynep Esenkaya, Bagci, Zafer, Kara, Aziz   +3 more
core   +1 more source

The impact of stigma surrounding use of medications for opioid use disorder. [PDF]

, 2020
Substance use disorders (SUDs) are highly stigmatized conditions, with stigma hindering and discouraging individuals from seeking treatment services. Not only does stigma exist for individuals with SUDs, but also for individuals who use medications to ...

core  

Making alcohol and tobacco preventable deaths truly preventable! Addiction as a modifiable risk factor for alcohol and tobacco preventable mortality

Archives of Public Health
Worldwide, health professionals from all specialties are encouraging patients to reduce alcohol use if not abstain, and abstinence is clearly encouraged for tobacco.
Emmanuelle Baillet, Fuschia Serre, Marc Auriacombe   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Substance use disorders: above and beyond addiction [PDF]

Substance Use Disorder (SUD) is a mental disorder that causes an individual to compulsively consume legal or illegal drugs such as alcohol, opioids, methamphetamine, marijuana, and medications, despite harmful consequences.

core   +1 more source

Clinical strategies for low-dose overlap initiation of buprenorphine and potential barriers to use [PDF]

Mental Health Clinician
Austin Smith, PharmD, BCPP, Kaitlyn Weslosky, PharmD, BCPP, Ashley Haynes, MD, December Crew, PharmD   +3 more
doaj   +1 more source

Impulsivity mediates the association between narcissism and substance-related problems beyond the degree of substance use: a longitudinal observational study

BMC Psychiatry
Background Narcissism has been implied as a putative risk factor for substance use disorders (SUDs). However, previous research did not disentangle the degree of substance use from substance-related problems, the symptoms of SUDs.
Malin K. Hildebrandt, Josepha Noack, Raoul Wuellhorst, Tanja Endrass, Emanuel Jauk   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source