Results 201 to 210 of about 15,613,357 (259)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Autism Spectrum Disorder and Co-occurring Substance Use Disorder – A Systematic Review

Substance Abuse: Research and Treatment, 2016
Espen Ajo Arnevik, Sissel Berge Helverschou   +1 more
doaj  

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Substance Use and Substance Use Disorders

2023
Abstract Substance use (SU) and substance use disorders (SUDs) represent major public health and clinical problems and have their roots in diverse domains in culture, the near social environment, and individual differences. Consequently, understanding both SU and SUD requires a multidisciplinary perspective that bridges diverse areas of ...
Kenneth J. Sher, W. E. Conlin, R. O. Pihl   +2 more
openaire   +2 more sources

Substance Use Disorders in the Elderly

Psychiatric Clinics of North America, 2022
The population of elderly in the United States with substance use disorders (SUDs) is growing appreciably. SUDs among the elderly are often associated with poor outcomes and are frequently underdiagnosed. The current diagnostic criteria are less sensitive in identifying SUDs among the elderly.
Rajesh R, Tampi, Deena J, Tampi, Alisandrea, Elson   +2 more
openaire   +2 more sources

Substance Use Disorders

Psychiatric Services, 1991
Adolescent substance use disorders are common illnesses that will be encountered in the primary care setting. Though they have been decreasing in prevalence recently, they still manifest in significant public health costs and increase the chance for negative life outcomes.
M, Schuckit, J, Helzer, T, Crowley, P, Nathan, G, Woody, W, Davis   +5 more
openaire   +2 more sources

Substance Use Disorders in Women

Psychiatric Clinics of North America, 2023
Substance use disorder (SUD) is among the leading causes of premature morbidity and mortality and imposes significant health, economic, and social burdens. Gender differences have been found in the development, course, and treatment of SUD, with women at increased risk for physiologic and psychosocial consequences compared with men.
Kathryn, Polak, Nancy A, Haug, Pamela, Dillon, Dace S, Svikis   +3 more
openaire   +2 more sources

Adolescent Substance Use Disorders

NEJM Evidence, 2022
Adolescent Substance Use DisordersSubstance use disorders contribute to the leading causes of death among adolescents, including homicide and suicide. Here, Simon et al. review the most recent published data on adolescent substance use disorders and the implications for clinical practice.
Kevin M, Simon, Sharon J, Levy, Oscar G, Bukstein   +2 more
openaire   +2 more sources

Substance Use Disorders

2016
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Nagel, J.E.L. van der, Duijvenbode, N. van, Didden, H.C.M.   +2 more
openaire   +3 more sources

Substance use disorder and personality disorder

Current Psychiatry Reports, 2002
Personality disorders (PDs) and substance use disorders (SUDs) frequently co-occur in both the general population and in clinical settings. Literature is reviewed documenting high comorbidity between these two classes of disorders, possible mechanisms of comorbidity, and the clinical implications of this comorbidity.
Kenneth J, Sher, Timothy J, Trull
openaire   +2 more sources