Results 131 to 140 of about 89,278 (236)

Effects of microbiota‐based interventions on depression and anxiety in children and adolescents—A systematic review

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract This study aims to systematically review evidence on gut microbiota‐based interventions for reducing depression‐ and anxiety‐like symptoms in children and adolescents with autism spectrum disorder, irritable bowel syndrome, Prader‐Willi syndrome, below‐average literacy skills or anorexia nervosa, where some individuals may exhibit indicators ...
Jiayu Hu, Yan Zhang, Chuwen Liu, Antigone Gkaravella, Jinyue Yu   +4 more
wiley   +1 more source

Construction and Validation of a Risk Prediction Model for Early Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT In the past several years, prediction models for severe intraventricular hemorrhage (IVH) in premature infants have emerged. However, few models have considered the importance of predictors related to the clinical course and hemostatic profile in predicting the risk of hemorrhage, such as the FiO2, hematocrit, and platelet count.
Fei Shen, Jie Xu, Hui Rong, Jing Zhang, Yang Yang, Xian‐Wen Li   +5 more
wiley   +1 more source

Synthesis of Poly (2‐hydroxyethyl ethyleneimine) and Its Mucoadhesive Film Formulations When Blended with Chitosan for Buccal Delivery of Haloperidol

Macromolecular Bioscience, EarlyView.
Mucoadhesive chitosan‐poly(2‐hydroxyethyl ethyleneimine) (P2HEEI) films were developed for buccal delivery of haloperidol. P2HEEI is synthesized by reacting linear polyethyleneimine with 2‐bromoethanol, achieving high solubility, low glass transition temperature, and biocompatibility.
Sitthiphong Soradech, Adrian C. Williams, Vitaliy V. Khutoryanskiy   +2 more
wiley   +1 more source

Benign Idiopathic Myoclonus: A New Clinical Entity?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Myoclonus is a brief shock‐like, involuntary movement, which can be distinguished in physiologic, essential, epileptic, and symptomatic, according to its etiology. Physiologic myoclonus typically occurs in healthy people without disability or progression.
Giorgia Sciacca, A.M. Madelein van der Stouwe, Sterre van der Veen, Hendriekje Eggink, Martje E. van Egmond, Jan Willem J. Elting, Marina A.J. Tijssen   +6 more
wiley   +1 more source

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert, David J.B. Kim, Meredith M. Miller, Sarah D. Atkinson, George B. Karkanias, Frederick E. Munschauer, Stephen P. Wanaski, Timothy M. Cunniff   +7 more
wiley   +1 more source

The Persistence of Dopamine Dysregulation Syndrome after Pallidal Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopamine dysregulation syndrome (DDS) is a debilitating complication of Parkinson's disease (PD) dopamine replacement therapy (DRT) in which patients pathologically and/or compulsively use dopaminergic drugs to treat motor symptoms. Studies examining DDS outcomes following deep brain stimulation (DBS) are limited and have focused on
Natalie David, Stewart A. Factor, Richa Tripathi, Lenora Higginbotham   +3 more
wiley   +1 more source

Subjective Well‐Being and Its Predictors in Parkinson's Disease and Dystonia: A Comparative Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Quality of life (QoL) is a commonly used outcome measure in people with chronic neurological diseases (CND). As valuable as QoL is, it does not take into account aspects of subjective well‐being (SWB) such as subjective happiness, meaning in life, life satisfaction and hope; all constructs that are considered central to well‐being ...
Suzette Shahmoon, Dejan Georgiev, Paul Jarman, Kailash Bhatia, Patricia Limousin, Marjan Jahanshahi   +5 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, EarlyView.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source