Results 121 to 130 of about 40,064 (263)

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Validation of an instrument to evaluate the signs and symptoms of benzodiazepine withdrawal

Revista Contexto & Saúde
Objective: to develop and validate an instrument to evaluate signs and symptoms that may occur during the process of deprescribing benzodiazepines in elderly Brazilian people.
Marlon Silva Tinoco, Letícia Maria Ribeiro, Ricardo Augusto dos Santos Silva, Luciana Soares Rodrigues, Luanna Gabriella Resende da Silva, Mariana Linhares Pereira, André Oliveira Baldoni   +6 more
doaj   +1 more source

Systematic mixed‐study review of nonpharmacological management of neonatal abstinence syndrome

, 2019
Background: Neonatal abstinence syndrome is a multi-system disorder resulting from exposure to maternal addictive substance use in pregnancy. Withdrawal is characterized by neonatal tremors, feeding difficulties and sleep disruption.
Lauren E. Kelly, Sonya MacVicar, Kelly, Lauren E., MacVicar, Sonya   +3 more
core   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Dezocine modulates the reinstatement of conditioned place preference in morphine-dependent rats via the dopamine reward circuitry

Frontiers in Neuroscience
IntroductionOpioid addiction is a significant public health issue, with existing treatments such as buprenorphine and methadone exhibiting limitations, including side effects and insufficient prevention of relapse. Novel therapeutic strategies are needed
Yan He, Yan He, Zhi-Sheng Piao, Yi Jia, Hui-Qi Wu, Xiao-Qiang Wang, Xiao-Qiang Wang, Wei-Feng Yu, Wei-Feng Yu, Wei-Feng Yu, Fei-Xiang Wu, Fei-Xiang Wu   +11 more
doaj   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

"--are you gonna wait until it kills you or are you gonna kill it?'' : narratives of individuals dependent on crystal methamphetamine

, 2008
Includes bibliographical references (leaves 125-136).The aim of this study was to investigate the current crystal methamphetamine problem and its trends of abuse as manifested in the local context of Cape Town, South Africa.
Ajodah, Anju
core  

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Exercise As An Adjuvant For Post-acute Withdrawal Syndrome In Substance Use Disorder

Medicine & Science in Sports & Exercise, 2019
Raj Masih, Michael Landis, Barbra Masih, Kabeer Masih, Justin Bates   +4 more
openaire   +2 more sources

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source