Results 131 to 140 of about 1,718,878 (260)
Chronic Diseases and Translational Medicine, EarlyView.Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley +1 more source
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
A conversation with James V. Zidek
Canadian Journal of Statistics, EarlyView.AbstractThis article documents a series of exchanges between the authors and the senior Canadian statistician Jim Zidek in early 2026. The interview traces his life trajectory, surveying his principal contributions to statistics while offering insights into his motivations, successes, and challenges. Zidek is a Fellow of the Royal Society of Canada and
Christian Genest, Nancy E. Heckman
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Over the last several decades, substance use, and associated harms have increased in both the United States and Canada. Physiological dependence is a predictable response to regular opioid and/or alcohol use and is responsible for the symptoms of ...
Ti, Lianping +3 more
core
Clinical Pharmacology &Therapeutics, EarlyView.Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer +10 more
wiley +1 more source
The hidden burden of sleep in adolescents with idiopathic generalized epilepsy
Epileptic Disorders, EarlyView.Abstract Background Idiopathic Generalized Epilepsies (IGEs) are electroclinical syndromes characterized by distinct seizure types, EEG patterns, and presumed polygenic inheritance. While seizure prognosis is often favorable, sleep disturbances, behavioral and emotional difficulties, and executive function impairment are common, especially during ...
Carlo Alberto Quaranta +8 more
wiley +1 more source
Predicting Sustainable Retirement Withdrawal Rates Using Valuation and Yield Measures [PDF]
This study attempts to quantify whether a 4 percent withdrawal rate can still be considered as safe for U.S. retirees in recent years when earnings valuations have been at historical highs and the dividend yield has been at historical lows.
Pfau, Wade Donald
core
Epileptic Disorders, EarlyView.Abstract Objective This study aimed to investigate the association between methylmalonic acid (MMA) and epilepsy prevalence and to explore potential inflammatory and nutritional pathways underlying this association. Methods This study included adults aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2014.
Ningyu Wei +5 more
wiley +1 more source