Results 101 to 110 of about 1,718,878 (260)

Social indicators associated with substance abuse

open access: yes, 1997
Cover title.; "Prepared for Connecticut's Department of Mental Health and Addiction Services as part of its Substance Abuse Prevention Needs Assessment, (CSAP Contract #277-95-1037)."; "March 1997."; Accompanied by appendices.; Funded by the U.S.
Stein-Seroussi, Alan.
core   +1 more source

Spending flexibility and safe withdrawal rates [PDF]

open access: yes
Shortfall risk retirement income analyses offer little insight into how much risk is optimal, and how risk tolerance affects retirement income decisions.
Pfau, Wade Donald   +2 more
core  

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad   +4 more
wiley   +1 more source

ADHD IN ADULTS: COMORBODITY WITH BIPOLAR DISORDER AND SUBSTANCE ABUSE [PDF]

open access: yes, 2011
ADHD is characterized by a continuous history of hyperactivity, forgetfulness, distractibility, impulsiveness and/or inattention, starting from the early childhood and at a more severe extent than whatever may be usual in peers.
CERAUDO, GIUSEPPE
core  

Propranolol withdrawal syndrome. [PDF]

open access: yes
Introduction. Propranolol, a non-selective beta-blocker widely used for the treatment of various cardiovascular diseases. However, its abrupt discontinuation can lead to withdrawal syndrome.This syndrome manifests as increased adrenergic sensitivity ...
Žemaitis, Augustinas,   +1 more
core   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum   +5 more
wiley   +1 more source

Capital market expectations, asset allocation, and safe withdrawal rates [PDF]

open access: yes
Most retirement withdrawal rate studies are either based on historical data or use a particular assumption about portfolio returns unique to the study in question. But planners may have their own capital market expectations for future returns from stocks,
Pfau, Wade Donald
core  

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis   +4 more
wiley   +1 more source

Changes in client functioning during treatment at a secondary stage addiction facility: an analysis of case records [PDF]

open access: yes, 2014
Recent findings indicate that South Africa and, in particular, the Western Cape has some of the highest prevalence of substance use disorders and substance related problems in the world.
Hazell, Nic
core   +1 more source

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