Results 161 to 170 of about 1,718,878 (260)

Gabapentin for the Management of Suspected Cannabis Withdrawal in a Pregnant Patient With a History of Cannabinoid Hyperemesis Syndrome: A Case Report. [PDF]

Case Rep Obstet Gynecol
Turcotte AM, Lemieux-Bourque C, McCarey C, Lévesque K, Kerkerian G, Labrecque AA.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Trends in opioid-, alcohol-, and drug-related mortality among US children aged 0-4 years: an analysis of the CDC WONDER Database trends, 1999-2023. [PDF]

Eur J Pediatr
Geiger T, Shahmohammadi Arani R, Haase K, Foley OA, Tauseef A.   +4 more
europepmc   +1 more source

Optimizing polytherapy management for Dravet syndrome in the United States: A National Expert Consensus

Epilepsia Open, EarlyView.
ABSTRACT Objectives Dravet syndrome (DS) is a severe, drug‐resistant developmental and epileptic encephalopathy (DEE) that requires polytherapy for adequate seizure control. The need to combine multiple antiseizure medications (ASMs), together with variability in seizure types, safety considerations, and evolving patient needs, makes treatment ...
Elaine Wirrell, Joseph Sullivan
wiley   +1 more source

Sustained seizure reduction, treatment simplification, and high retention with cenobamate: A 12‐month real‐world study in refractory and ultra‐refractory focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective To assess the 12‐month clinical impact of cenobamate (CNB) in adults with drug‐resistant focal epilepsy in clinical practice, exploring whether outcomes differed according to prior antiseizure medication (ASM) exposure. Methods This single‐center, retrospective, observational, real‐world study included 91 adults stratified by the ...
Francesca Cutropia, Maria Teresa Di Claudio, Marta Robustella, Umberto Costantino, Carmela Pia Ferro, Giuseppe Miscio, Elena Conte, Nicola Amoroso, Orazio Nicolotti, Cosimo Damiano Altomare, Massimo Carella, Antonella Liantonio, Paola Imbrici, Giuseppe d'Orsi   +13 more
wiley   +1 more source

Depression in Opioid Use Disorder: A Tripartite Psychopathological Model for Dual Disorders. [PDF]

J Clin Med
Maremmani AGI, Della Rocca F, Bacciardi S, Cimino S, Cerniglia L, Pallucchini A, Carbone MG, Miccoli M, Maremmani I.   +8 more
europepmc   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Long‐term developmental outcome in infantile epileptic spasms syndrome after high‐dose prednisolone and vigabatrin treatment

Epilepsia Open, EarlyView.
Abstract Objective To evaluate long‐term developmental outcomes and identify independent predictors of favorable developmental outcomes at 3 years of age in children with infantile epileptic spasms syndrome (IESS) treated with a standardized stepwise vigabatrin and high‐dose prednisolone protocol.
Soyoung Jang, Hui Jin Shin, Se Hee Kim, Joon Soo Lee, Ara Ko, Hoon‐Chul Kang   +5 more
wiley   +1 more source

Psychopharmacological Prescribing Patterns Among Italian Adolescents With Anorexia Nervosa: Exploring Real‐World Treatment Practices

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To investigate real‐world psychopharmacological prescribing patterns among Italian adolescents with anorexia nervosa (AN) compared with psychiatric controls without eating disorders, and to examine whether AN diagnosis independently predicts medication use after accounting for psychiatric comorbidities.
Marika Orlandi, Arianna Vecchio, Giulia Andorno, Maria Pia Riccio, Cinzia Crispino, Martina Maria Mensi   +5 more
wiley   +1 more source