Results 301 to 310 of about 123,845 (338)
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Death in the substantia nigra: a motor tragedy
Expert Review of Neurotherapeutics, 2007It is well known that the death of dopaminergic neurons of the substantia nigra pars compacta (SNc) is the pathological hallmark of Parkinson's disease (PD), the second most common and disabling condition in the expanding elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and ...
ESPOSITO E +2 more
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Hyperechogenicity of the Substantia Nigra in Parkinson's Disease
Journal of Neuroimaging, 2007ABSTRACTSubstantia nigra (SN) was assessed by transcranial sonography (TCS) in 47 Parkinson's disease (PD) patients and in 39 healthy volunteers. A semiquantitative echogenicity scale was created with arbitrary values ranging from 1 to 5, zones with grade ≥3 and larger than 0.19 cm2 were recorded as hyperechogenic SN.
David Školoudík +3 more
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Ultrastructure of developing substantia nigra in humans
International Journal of Developmental Neuroscience, 1996AbstractElectron microscopy of the maturing neurons and developing and maturing synapses in the substantia nigra of 14 human embryos/foetuses of 8–24 weeks of gestation are reported. At 8 weeks, cells were immature with very little cytoplasm and cellular organelles. Contact sites of processes appeared more electron dense than the other areas.
K. Sailaja, Gomathy Gopinath
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Culture of Substantia Nigra Neurons
Current Protocols in Neuroscience, 1997AbstractPrimary cultures of nigral tissue are widely used as a model system to assay effects of trophic and toxic agents on dopaminergic neurons. Cultured dopaminergic neurons have been successfully transplanted in animals and led to behavioral improvement in animal models of Parkinson's disease.
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Neuromelanin and RNA in Cells of Substantia Nigra
Journal of Neuropathology & Experimental Neurology, 1977We have found that with accumulation of neuromelanin granules within cell bodies of neurones of the human substantia nigra there is a reduction in cytoplasmic RNA and a decrease in nucleolar volume. These observations imply a gradual decrease in the functional capacity of the cell such that eventually, the cell is unable to produce sufficient protein ...
D. M. A. Mann, P. O. Yates, C. M. Barton
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Cholinergic neurons in the rat substantia nigra
Neuroscience Letters, 1986The distribution of choline acetyltransferase (ChAT)-like immunoreactivity (LI), demonstrated according to an avidin-biotin procedure, was evaluated in the substantia nigra (SN) of rats. Although ChAT positivity was considerably less in the nigral neuropil than in the interpeduncular nucleus, it was also higher, particularly in caudal pars reticulata ...
Larry L. Butcher, Elizabeth Gould
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Mitochondrial DNA polymorphism in substantia nigra
Journal of the Neurological Sciences, 1996Inefficiencies in mitochondrial respiration mainly affecting complex I and IV activities, occur with increasing age and have been suggested as a possible etiological factor in age-related neurodegenerative diseases. It has been suggested that this finding may be explained by an accumulation of mtDNA mutations.
Nuryati Chairani Siregar +8 more
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The striatum and substantia nigra: A commentary on their relationships
Neuroscience, 1979Publisher Summary The greatest focus of attention in recent years regarding the functions of the basal ganglia has been given to examining the interrelationships between the striatum (caudate and putamen) and the substantia nigra . These structures, like others of the basal ganglia, are involved in the control of posture and locomotion, the ...
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Ontogeny of Substantia Nigra Dopamine Neurons
2009Understanding the ontogeny of A9 dopamine (DA) neurons is critical not only to determining basic developmental events that facilitate the emergence of the substantia nigra pars compacta (SNc) but also to the extraction and de novo generation of DA neurons as a potential cell therapy for Parkinson's disease.
Monte A. Gates +2 more
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HEMIPARKINSONISM WITH INFARCTION OF THE IPSILATERAL SUBSTANTIA NIGRA
Neuropathology and Applied Neurobiology, 1978An elderly man suffering from dementia associated with hypertension developed right‐sided parkinsonism marked by rigidity and flexion. At autopsy the brain showed generalized vascular changes chiefly in the white matter, diffuse plaque and neurofibrillary tangle formation in the temporal cortex, and a discrete gliotic scar in the right substantia nigra.
J. Smith +3 more
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