Results 51 to 60 of about 533,211 (252)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Turning Feminist Judgments into Jurisprudence: The Women’s Court of Canada on Substantive Equality
Oñati Socio-Legal Series, 2018 The Women’s Court of Canada project is unique in having chosen to focus its rewriting efforts in a specific area of law – constitutional equality cases.
Denise Réaume
doaj
The Windsor Yearbook of Access to Justice, 2015 In 2006, the United Nations adopted the Convention on the Rights of Persons with Disabilities [CRPD], the first international treaty addressing specifically the rights of people with disabilities, including in the workplace.
Arlene S Kanter
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Substantive equality and transformation in South Africa [PDF]
, 2007 This article considers whether ‘substantive equality’, as a transformative idea and legal mechanism in the South African Constitution, can generate legal solutions and court decisions that may result in transformative change. It does so by establishing a
Albertyn, Catherine
core
Gender Equality Reforms in Parliaments
Politics and GovernanceGender equality reforms implemented across various parliaments around the world have diversified. Introducing the thematic issue Gender Equality Reforms in Parliaments, we trace the context of making parliamentary institutions more gender-sensitive.
Petra Ahrens, Sonia Palmieri
doaj +1 more source
Race and Rights in the Digital Age
AJIL Unbound, 2018 This essay discusses how, despite the liberatory potential of technology, racial bias pervades the digital space. This bias creates tension with both the formal, de jure equality notion of “colorblindness” (in U.S.
Catherine Powell
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Constitutionalization of the Right to Abortion from Different Understandings of Autonomy
AthenaThis article explores the constitutionalization of abortion in Mexico within the broader framework of Latin American constitutionalism. It highlights the pivotal institutional reforms of 1994 and 2011 that redefined the role of the Mexican Supreme Court ...
Ana Micaela Alterio
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source