Results 161 to 170 of about 9,273,531 (285)

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

Spectral studies of substituent effects in some diphenyl sulfide derivatives

, 2003
1471-1477Hammett relationship for λn-* indicates that substituent effects are purely polar while 1H NMR studies suggest that 4'arylthio-3'-nitrobenzotrifluoride 4a-i do not exist in the skew conformation.
Batterjee, S M
core  

Concerted Proton-Electron Transfer Minimizes Substituent Effects on Adsorbed Phthalocyanine Electrocatalysis. [PDF]

J Am Chem Soc
Mannava V, Smith LE, Gardner JG, Hammes-Schiffer S, Surendranath Y.   +4 more
europepmc   +1 more source

Unlocking Li/Mg‐Based Photochemical Nitration Platforms for Anticancer Drug Discovery

Advanced Science, EarlyView.
Two low‐toxicity light main‐group metal photochemical systems based on lithium and magnesium are constructed for selective C(sp2)‐H (di)nitration of anilines. The obtained dinitrated products exhibit anti‐HCC (hepatocellular carcinoma) and anti‐KYSE30 cell activities, holding promise as novel antitumor candidates.
Qian Wan, Jiali Zhu, Shanshuo Liu, Luchuan Ou, Huizhen Wang, Yu Lan, Zhou Dong, Yihang Bai, Wei Yang, Shihan Liu, Yan Qiao, Shi‐Jun Li, Zhigang Ren, Linbin Niu   +13 more
wiley   +1 more source

Catechol-derived propargyl diol cyclizations with malonyl dichloride: substituent effects on the formation of macrocyclic esters and their hydrochlorinated adducts. [PDF]

RSC Adv
Lefkaritis G, Kourtellaris A, Chronakis N, Georgiades SN.   +3 more
europepmc   +1 more source

Improving Molecular Iron Ammonia Oxidation Electrocatalysts via Substituent Effects That Modulate Standard Potential and Stability. [PDF]

ACS Catal, 2023
Zott MD, Peters JC.
europepmc   +1 more source

The In Situ Electrochemical−Chemical Cascade Strategy for Pyruvic Acid Synthesis

Advanced Science, EarlyView.
By employing an “unsaturation−oxygen coordination engineering” strategy, the local coordination environment is regulated to achieve efficient electrochemical synthesis of H2O2. Importantly, an electrochemical−chemical coupled cascade strategy is utilized for the efficient preparation of pyruvic acid via lactic acid oxidation. ABSTRACT Hydrogen peroxide
Xueli Mei, Huawei Zhuo, Yu Liu, Lili Wang, Yudai Huang, Hongtao Xie, Yizhao Li   +6 more
wiley   +1 more source

Substituent Effects Govern the Efficiency of Isoxazole Photoisomerization to Carbonyl‑2<i>H</i>‑Azirines. [PDF]

ACS Org Inorg Au
Jackson KE, Szeto I, Seebald LM, Shepard SG.   +3 more
europepmc   +1 more source

Architected Spatially Deterministic Multiscale Phase Segregation in Block Copolymer Composites for Augmented Radiative Cooling

Advanced Science, EarlyView.
Multiscale phase segregation in block copolymers enables spatially deterministic structuring from molecular to macroscopic scales, decoupling solar scattering and infrared emission for augmented radiative cooling. ABSTRACT Passive radiative cooling, which reflects solar irradiation while emitting heat through the atmospheric window, provides a ...
Mingxin Feng, Feiyang Zhou, Haoran Cai, Wenchao Zhai, Shuangjiang Feng, Yanmei Liu, Xiaohai Bu, Man He, Dudong Feng, Shuang Liang, Yuming Zhou   +10 more
wiley   +1 more source

Substituent effects of fluorinated bambusurils on their anion transport. [PDF]

Org Biomol Chem
Chvojka M, Šindelář V, Valkenier H.
europepmc   +1 more source