Results 91 to 100 of about 1,615,147 (290)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

S-Boxهای پویای وابسته به کلید سبک وزن مبتنی بر ابرخم بیضوی برای دستگاه¬های اینترنت اشیا

علوم رایانش و فناوری اطلاعات, 2021
Security is one of the main issues in Internet of Things (IoT). Encryption plays a curtail role in making these systems secure. Substitution Box (S-Box) has an effective impact in block encryption methods. Due to the restricted resource capacities of IoT
پروانه اصغری, سید حمید حاج سید جوادی   +1 more
doaj  

Block Cipher's Substitution Box Generation Based on Natural Randomness in Underwater Acoustics and Knight's Tour Chain. [PDF]

Comput Intell Neurosci, 2022
Khan MF, Saleem K, Shah T, Hazzazi MM, Bahkali I, Shukla PK.   +5 more
europepmc   +1 more source

Lorenz and Chua Chaotic Key-Based Dynamic Substitution Box for Efficient Image Encryption

With the growing demand for secure image communication, effective encryption solutions are critical for safeguarding visual data from unauthorized access.
Sathish Kumar Gurunathan Arthanari, Sarala Boobalan   +1 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Example of substitution matrix.

, 2017
Figure showing overlapping peptides (left) with the valine (V highlighted in bold) being analyzed for antibody selectivity. The box contains the substitution values, xi,j, with columns representing the amino acid, i, which substitutes valine and rows ...
Søren Buus (49944), Thomas Østerbye (337454), Morten Nielsen (33408), Ole Lund (26628), Christian Skjødt Hansen (3663679), Paolo Marcatili (45578)   +5 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Human Psychological Disorder towards Cryptography: True Random Number Generator from EEG of Schizophrenics and Its Application in Block Encryption's Substitution Box. [PDF]

Comput Intell Neurosci, 2022
Khan MF, Saleem K, Hazzazi MM, Alotaibi M, Shukla PK, Aqeel M, Tuncer SA.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source