Results 81 to 90 of about 480,128 (291)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
An Algebraic Weak Factorisation System on 01-Substitution Sets: A Constructive Proof
, 2016 We will construct an algebraic weak factorisation system on the category of 01 substitution sets such that the R-algebras are precisely the Kan fibrations together with a choice of Kan filling operation.
Swan, Andrew
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Dynamical properties of almost repetitive Delone sets
, 2013 We consider the collection of uniformly discrete point sets in Euclidean space equipped with the vague topology. For a point set in this collection, we characterise minimality of an associated dynamical system by almost repetitivity of the point set.
Frettlöh, Dirk, Richard, Christoph
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
S-Box on Subgroup of Galois Field
Cryptography, 2019 In substitution−permutation network as a cryptosystem, substitution boxes play the role of the only nonlinear part. It would be easy for adversaries to compromise the security of the system without them.
Tariq Shah, Ayesha Qureshi
doaj +1 more source
Outsourcing of services, imported materials and the demand for heterogeneous labour : an application of a generalised box-cox function [PDF]
This paper examines the effects that purchased services and imported intermediate materials have on the labour demand for different skills in the manufacturing sector.
Falk, Martin, Koebel, Bertrand M.
core