Results 191 to 200 of about 2,216,866 (310)

Cleavage of MEP-1 by DPF-3 reveals novel substrate specificity and its impact on reproductive fitness. [PDF]

EMBO Rep
Aygün I, Amanullah A, Seebacher J, Hess D, Soneson C, Roy A, Großhans H, Gudipati RK.   +7 more
europepmc   +2 more sources

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Experimental and In Silico Approaches to Study Carboxylesterase Substrate Specificity. [PDF]

J Xenobiot
Ribone SR, Quevedo MA.
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Determinants of substrate specificity in mint pulegone reductase, a double bond reductase of the medium-chain dehydrogenase/reductase superfamily. [PDF]

J Biol Chem
Andrews AJ, Lange I, Srividya N, Lange BM.   +3 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Characterization of a <i>β</i>-Glucosidase from <i>Fragaria × ananassa</i>: Substrate Specificity, Catalytic Efficiency, and Structural Insights. [PDF]

Foods
Rabeeah I, Zavarise A, Manghi A, Gruber-Schmidt V, Hackl M, Paltram R, Gössinger M, Cattani L, Stich K, Sheehan H, Halbwirth H, Haselmair-Gosch C.   +11 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation. [PDF]

Commun Biol
Matlack JK, Miner RE, Lokhandwala J, Binning JM.   +3 more
europepmc   +1 more source

Substrate specificity of plant peroxidases

FEBS Letters, 1971
Chmièlnicka, J., Ohlsson, P.-I., Paul, K.-G., Stigbrand, T.   +3 more
openaire   +2 more sources