Results 311 to 320 of about 660,873 (335)

Computation of enzyme-substrate specificity

Biochemistry, 1981
The present study reports the development of a new procedure for teh theoretical computation of enzyme-substrate specificities. The immediate goal has been to identify experimental data with which computations may be effectively compared, examine the underlying theoretical principles, and demonstrate feasibility.
openaire   +3 more sources

Specifying Substrate Specificity

Science Signaling, 2013
Distinct intracellular signaling pathways acting on the substrates of a protease could determine which substrates are cleaved.
openaire   +2 more sources

Substrate Specificity of MMPs

2003
Matrix metalloproteinases (MMPs) are secreted or cell surface-bound zinc metalloendopeptidases that act on extracellular matrix (ECM) macromolecules. Thus, isolated MMPs have been tested against various components of ECM. Based on similarities in primary structure and the abilities to cleave ECM components, MMPs are grouped into collagenases ...
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Modifying the substrate specificity of chymosin

Biochemical Society Transactions, 1991
Merja Penttilä, J. E. Pitts, Janna Uusitalo, Dimitris Mantafounis, Sean E. Lawler, Peter Strop, Dominic Quinn   +6 more
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Adhesives for Specific Substrates

2018
The service environment is at least as important in the selection of an adhesive as the nature of the surfaces. The characteristics required of an adhesive which must withstand a low static load under ambient temperature and low-humidity conditions are vastly different from those required of a product which must endure large cyclic stresses in a moist,
openaire   +2 more sources

Noncoding RNA therapeutics — challenges and potential solutions

Nature Reviews Drug Discovery, 2021
Sherien M El-daly, Muller Fabbri, George A Calin   +2 more
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Targeting multidrug resistance in cancer

Nature Reviews Drug Discovery, 2006
Gergely Szakács, Michael M Gottesman
exaly  

The benefit and cost of prostate cancer early detection. The Investigators of the American Cancer Society-National Prostate Cancer Detection Project

Ca-A Cancer Journal for Clinicians, 1993
Takeshi Nishiyasu
exaly  

Substrate Directed Asymmetric Reactions

Chemical Reviews, 2018
Sukalyan Bhadra, Hisashi Yamamoto
exaly