Results 71 to 80 of about 10,438,012 (377)
Substrate specificity of prostate-specific antigen (PSA)
Chemistry & Biology, 1998 The serine protease prostate-specific antigen (PSA) is a useful clinical marker for prostatic malignancy. PSA is a member of the kallikrein subgroup of the (chymo)trypsin serine protease family, but differs from the prototypical member of this subgroup, tissue kallikrein, in possessing a specificity more similar to that of chymotrypsin than trypsin. We
Coombs, Gary +8 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2019 Plants have various color pigments. Many plants have fruits and flowers of vivid colors such as orange, red, purple and blue. Anthocyanins with anthocyanidins as aglycone are one group of plant pigments.
古川, 一実 +3 more
core
Directed enzyme evolution: climbing fitness peaks one amino acid at a time [PDF]
, 2009 Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse.
Arnold, Frances H., Tracewell, Cara A.
core +2 more sources
Biotechnology for Biofuels, 2015 BackgroundThe understanding of enzymatic polysaccharide degradation has progressed intensely in the past few years with the identification of a new class of fungal-secreted enzymes, the lytic polysaccharide monooxygenases (LPMOs) that enhance cellulose ...
C. Bennati-Granier +11 more
semanticscholar +1 more source
Substrate specificity of ceramide trihexosidase
FEBS Letters, 1972 Artificial substrates such as 4-methylumbelliferyl glycosides and p-nitrophenyl glycosides have been employed commonly to determine the levels of glycosyl hydrolase activities in plasma, urine and tissues [l-7]. They have provided a simple and rapid method for the diagnosis of some lysosomal storage diseases, whereas in other instances inconsistencies ...
Carol A. Mapes, Charles C. Sweeley
openaire +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
A P-type ATPase importer that discriminates between essential and toxic transition metals [PDF]
, 2009 Transition metals, although being essential cofactors in many physiological processes, are toxic at elevated concentrations. Among the membrane-embedded transport proteins that maintain appropriate intracellular levels of transition metals are ATP-driven
A. T. Lee +25 more
core +2 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Polyhydroxyalkanoate (PHA) synthases (PhaCs) are key enzymes in PHA polymerization. PhaCs with broad substrate specificity are attractive for synthesizing structurally diverse PHAs.
Ramamoorthi M Sivashankari +7 more
doaj +1 more source