Results 101 to 110 of about 1,236,959 (315)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The Effect of Different Substrates on the Phenotype, Nutritional, Phytochemical Composition and Antioxidant Activity of Pleurotus Pulmonarius

open access: yesFundamental and Applied Agriculture
Mushrooms have been an important food to man for millennia. Several species of Pleurotus have been cultivated successfully on different substrates including palm bunch, sawdust and corn cob.
Zenas Chisom Agubata   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

/Si Substrates with Fast Photoresponse

open access: yes, 2019
Re‐based transition metal dichalcogenides (TMDs) and alloys have many unusual features such as in‐plane anisotropic optical, electrical, and phonon properties and thus receive increasing research interest.
Peipei Kang   +15 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

New Generation of LTCC Materials

open access: yesBoletín de la Sociedad Española de Cerámica y Vidrio, 2004
To reduce the complexity of LTCC systems and so accelerate the development of LTCC tapes with new functionalities it is necessary to reduce the number of phases within a particular tape.
Valant, Matjaz, Suvorov, Danilo
doaj  

The relation between preference and demand for litter substrates in the domestic hen

open access: yes, 2006
Six hen's preferences between 5-min access to each of two litter substrates, sand and sawdust, were measured using dependent concurrent VI 60 s VI 60 s schedules of reinforcement. The obtained preferences were small and idiosyncratic.
Harris, Aimee Rebecca
core  

Denitrification potential in a grassland subsoil: effect of carbon substrates

open access: yes, 2004
We examined the potential of a subsoil to denitrify nitrate under optimal anaerobic conditions in a laboratory-based incubation when supplied with a range of C substrates of increasing recalcitrance.
Hatch, D. J.   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influencia del substrato sobre las propiedades ferroeléctricas de láminas delgadas de PTCa

open access: yesBoletín de la Sociedad Española de Cerámica y Vidrio, 1999
The ferroelectric properties of calcium modified lead titanate (Pb0.76Ca0.24)TiO3 (PTCa) thin films prepared by a sol - gel method with successive crystallisations on three different substrates (A) Pt / Ti / SiO2 / Si (100), (B) Ti / Pt / Ti / SiO2 / Si ...
Jiménez, R.   +4 more
doaj  

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