Results 91 to 100 of about 2,340,556 (352)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications

Biomimetics
The surface topography of substrates is a crucial factor that determines the interaction with biological materials in bioengineering research. Therefore, it is important to appropriately modify the surface topography according to the research purpose ...
Sunhee Yoon, Ahmed Fuwad, Seorin Jeong, Hyeran Cho, Tae-Joon Jeon, Sun Min Kim   +5 more
doaj   +1 more source

Lateral and normal forces between patterned substrates induced by nematic fluctuations

, 2005
We consider a nematic liquid crystal confined by two parallel flat substrates whose anchoring conditions vary periodically in one lateral direction. Within the Gaussian approximation, we study the effective forces between the patterned substrates induced
F. Karimi Pour Haddadan, P. G. de Gennes, P. M. Chaikin, S. Dietrich   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mudas de eucalipto produzidas a partir de miniestacas em diferentes recipientes e substratos Eucalyptus stecklings produced in different containers and substrates

Revista Árvore, 2006
Este trabalho teve como objetivo avaliar a qualidade de mudas de híbridos naturais de Eucalyptus grandis e E. saligna produzidas a partir de miniestacas, em tubetes de 50 cc e em blocos prensados com as dimensões de 40 x 60 x 7cm.
Teresa A. S. de Freitas, Deborah G. Barroso, José G. de A. Carneiro, Ricardo M. Penchel, Fábio A. M. M. de A. Figueiredo   +4 more
doaj   +1 more source

A novel splice site mutation c.2278 (−1) G>C in the TMPRSS6 gene causes deletion of the substrate binding site of the serine protease resulting in refractory iron deficiency anaemia [PDF]

, 2009
Eunice Sindhuvi Edison, Rekha Athiyarath, Rajasekar Thirugnanam, Mark Westerman, Alok Srivastava, Mammen Chandy   +5 more
openalex   +1 more source

MRI substrates of specific neuropsychological dysfunctions within and across FTD genotypes at the presymptomatic and symptomatic disease stage

, 2021
Dominik David Wabersich-Flad
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Graphene microwave transistors on sapphire substrates

, 2011
We have developed metal-oxide graphene field-effect transistors (MOGFETs) on sapphire substrates working at microwave frequencies. For monolayers, we obtain a transit frequency up to ~ 80 GHz for a gate length of 200 nm, and a power gain maximum ...
A. C. Betz, B. Plaçais, C. Benz, E. Pallecchi, H. v. Löhneysen, Lee J., Lin Y.-M., Lin Y.-M., Meric I., Pozar D. M., R. Danneau   +10 more
core   +1 more source

Review for "Effects of different agro‐industrial waste as substrates on proximate composition, metals, and mineral contents of oyster mushroom ( Pleurotus ostreatus )"

, 2021
LINGAMALLU JAGANMOHANRAO
openalex   +1 more source