Results 71 to 80 of about 1,236,959 (315)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Bioscience Journal, 2016 Â Information on germination, seedling development, and substrates and water requirements of native Savannah species are scarce, for propagation and plantation establishments.
Daiane Mugnol Dresch +3 more
doaj +1 more source
Developments in the hydrogenation of challenging substrates utilising transition metal complexes
, 2014 This thesis describes the developments of new protocols for the hydrogenation of challenging substrates. Three specific substrates were highlighted for study after an initial review of the literature; benzofurans, esters and bulky ketones.
Ian Carpenter, Carpenter, Ian
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2016 A novel method for the determination of benzoic acid has been employed to identify carboxypeptidase activities in clinically relevant pathogens. Benzoic acid was determined after chemical derivatization by gas chromatography–mass spectrometry (GC–MS).
Dean, John +3 more
core +1 more source
A new substrate for sampling deep river macroinvertebrates [PDF]
, 2009 We compared macroinvertebrate communities colonising multiplate samplers constructed from perspex or tempered hardboard (wood) with an alternative artificial substrate constructed from folded coconut fibre matting (coir) enclosed in nylon netting ...
Hamer, Mark +3 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Revista Brasileira de Plantas Medicinais, 2009 O presente trabalho foi conduzido no Departamento de Produção Vegetal da Faculdade de Ciências Agronômicas da UNESP de Botucatu, durante o período de agosto a dezembro de 2006.
R.S. Mattana +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An In Silico Model for Classification of P-Glycoprotein Substrates and Non-Substrates
, 2005 : P-glycoprotein (P-gp) is one of the most important enzymes in ATP transporter family. It transports various foreign substances actively out of cells and, in this way, greatly influencing the ADME (absorption, distribution, metabolism and excretion ...
蒋达 +5 more
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