Results 51 to 60 of about 1,236,959 (315)
Molecules, 2021 The interaction of small organic molecules such as drugs, agrochemicals, and cosmetics with cytochrome P450 enzymes (CYPs) can lead to substantial changes in the bioavailability of active substances and hence consequences with respect to pharmacological ...
Malte Holmer +3 more
doaj +1 more source
Anthroposol development from limestone quarry substrates.
, 2013 Limestone quarry reclamation worldwide requires development of substrates or anthroposolic soils. The suitability of three limestone substrates (gray, gray brown, crushed) for revegetation was assessed in two greenhouse experiments.
Cohen-Fernández, A. C. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Brushing, a simple way to fabricate SERS active paper substrates [PDF]
, 2014 A simple and facile method has been demonstrated to fabricate low-cost surface enhanced Raman scattering (SERS) active microfluidic paper chips using a painting brush.
Gao, Dingxue +6 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Acta Scientiarum Polonorum: Hortorum Cultus, 2010 The aim of investigations conducted in the years 2005–2007 was to determine the chemical composition of nutrient solutions in the root environment of tomato grown in wood fiber and rockwool, under the influence of diverse levels of nitrate nitrogen in ...
Andrzej Komosa +2 more
doaj
EFFECT OF SUBSTRATES ON OYSTER MUSHROOM PRODUCTION [PDF]
, 2020 A Thesis Submitted to the Department of Horticulture, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE (MS ...
ASHA, ISMOTARA
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Carnosinases, Their Substrates and Diseases
Molecules, 2014 Carnosinases are Xaa-His dipeptidases that play diverse functions throughout all kingdoms of life. Human isoforms of carnosinase (CN1 and CN2) under appropriate conditions catalyze the hydrolysis of the dipeptides carnosine (β-alanyl-L-histidine) and homocarnosine (γ-aminobutyryl-L-histidine).
Bellia F +2 more
openaire +3 more sources