Results 31 to 40 of about 1,236,959 (315)

Novel Oxidative Coupling-Based Chromogenic Substrates for Horseradish Peroxidase-Enhanced Lateral Flow Immunoassays: A Highly Sensitive and Economical Alternative to Conventional Substrates

open access: yes, 2023
Lateral flow immunoassays (LFIAs) have become indispensable in point-of-care diagnostics, but improving their sensitivity remains a critical challenge. Here, we present a strategy to enhance LFA sensitivity by introducing novel oxidative coupling-based ...
Karan, Saxena, Bhushan, Toley
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Quad-Mode H-Beam Metasurface-Embedded Dual-Band Circularly-Polarized Multi-Tiered Antenna Scheme With 5G (n79) and Wi-Fi 6E Capabilities

open access: yesIEEE Access
This research proposes a quad-mode H-beam metasurface (MTS)-embedded dual-band circularly-polarized (CP) multi-tiered antenna scheme with 5G (n79) and Wi-Fi 6E capabilities.
N. Supreeyatitikul   +4 more
doaj   +1 more source

Microheated substrates for patterning cells and controlling development

open access: yes, 2005
Here, we seek to control cellular development by devising a means through which cells can be subjected to a microheated environment in standard culture conditions.
Wang, S.   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Enhancing Acclimatization Conditions for Vriesea splendens ‘Fire’: A Comparative Analysis of Substrate Effects on Growth and Survival

open access: yesPlants
This study investigates the acclimatization success of Vriesea splendens ’Fire’, a popular ornamental bromeliad, through in vitro propagation on various substrates. Due to the increasing demand for V.
Eman Abdelhakim Eisa   +2 more
doaj   +1 more source

Optimization of AZO films prepared on flexible substrates

open access: yes, 2017
Transparent conductive Al2O3-doped zinc oxide (in AZO, Al2O3 content is similar to 2 wt%) thin films are deposited on flexible polyethylene terephthalate (PET) substrates, using radio frequency (rf) magnetron sputtering. The Taguchi method with an L (9) (
Hu, C. C.;Lu, T. W.;Chou, C. Y.;Wang, J. T.;Huang, H. H.;Hsu, C. Y.   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety

open access: yesАнтибиотики и Химиотерапия, 2020
Tricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice.
E. V. Fomin   +3 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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