Results 141 to 150 of about 1,396,264 (316)

Finite element modal analysis of the FPD glass substrates handling robot

open access: yes, 2012
A planar multi-joint handling robot for FPD (Flat Panel Display) glass substrates with heavy load and high precision is introduced. In order to investigate the vibration characteristics of this robot, finite element modal analysis with Solidworks ...
Wang HG(王洪光), Cheng L(程丽)
core  

Electro-mechanical behaviour of indium tin oxide coated polymer substrates for flexible electronics [PDF]

open access: yes, 2012
Highly conductive (3.0 - 5.0 x 10 \(^{-4}\) \( \Omega\) cm) and transparent (80 – 85% ) ITO films were successfully fabricated on glass and polymer substrates (PET, PEN and PC) by pulsed laser deposition at low temperatures (24 – 150 °C).
Potoczny, Grzegorz A   +1 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Adsorption of primary substituted hydrocarbons onto solid gallium substrates [PDF]

open access: yes
Master of ScienceDepartment of ChemistryTakashi ItoAdsorption of a series of primarily substituted hydrocarbons (RX; C[subscript]18H[subscript]37PO(OH)[subscript]2 (ODPA), C[subscript]17H[subscript]35COOH, C[subscript]18H[subscript]37OH, C[subscript]18H ...
De Silva, Chrishani Maheshwari
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Creoles, their Substrates, and Language Typology

open access: yes
The distinct social origin of creoles, along with pidgins and mixed languages, makes them a source of interest to typologists, given their interest in the cross-linguistic distribution of structural feature values. Typologists, like creolists before them,
Lefebvre, Claire.
core  

Comparative study of InAs quantum dots grown on different GaAs substrates by MOCVD

open access: yes, 2005
We present a comparative study of InAs quantum dots grown on Si-doped GaAs (10 0) substrates, Si-doped GaAs (10 0) vicinal substrates, and semi-insulating GaAs (10 0) substrates.
Zhu, HL   +5 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

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