Results 101 to 110 of about 8,404 (278)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
GROWN AND SUBSTRUCTURE OF LITHIUM NIOBATE FILMS
Конденсированные среды и межфазные границы, 2019 Objective. Radio frequency magnetron sputtering (RFMS) is one of the most promising methods of synthesis of lithium niobate fi lms. It is known that RFMS conditions (the composition and the pressure of the working gas and the power and the spatial ...
Dybov Vladislav A. +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 2013 Formation of the cyclopenta[c]pyridine substructure using a novel one- and two-step method was examined using various linear 1,8-enedial substrates. Methods to prepare 1,8-enedial intermediates with appropriate functionality to form a small family of ...
Adler, Snow
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Substructure Synthesis Analysis and Hybrid Control Design for Buildings under Seismic Excitation
, 1997 We extend the application of the substructure synthesis method to more complex structures, and establish a design methodology for base isolation and active control in a distributed model of a building under seismic excitation.
Morales Velasco, César A.
core
Jixie chuandong, 2014 A gear modification method for wind turbine gearbox is proposed aiming at achieving minimum dynamic transmission error（DTE）.Firstly,a multibody dynamics model for the gearbox is established by using the substructure synthesis,in which the gearbox is ...
张俊, 郭凡
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source