Results 111 to 120 of about 8,404 (278)
Synthesis and reactivity of silylmethylcyclopropanes
, 2011 PhDSubstituted tetrahydrofurans (THFs) are common structural motifs found in natural products. The biological activity and structural complexity of these compounds makes their efficient construction with controlled regio- and stereochemistry a ...
Dunn, Jonathan
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Model Development and Stability Analysis for a Turbocharger Rotor System under Multi-Field Coupled Forces [PDF]
, 2012 Automotive turbochargers have been widely applied in vehicles in order to increase the power output of internal combustion engines by increasing the air to fuel ratio entering the piston cylinders.
Zhang, Hao
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Calculating required substructure damping to meet prescribed system damping levels [PDF]
, 2007 Structural synthesis is a method of calculating the transient dynamic response of an assemblage of substructures without explicitly assembling and solving a combined system model. While significant computational advantages are provided by this method,
Penetrante, Wendel D.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
An Efficient Response Analysis Method for a Structural System Using Substructure Modes
, 1993 An efficient method for determining forced responses of a general linear structural system in time domain using subtructure modes and Lagrange multipliers is presented.
박윤식, 김형근
core
, 1996 Based on a variational method adopting the dynamic pressure in the fluid and the acceleration in the solid as arguments in the functional, several substructure-subdomain methods are developed to describe the dynamical behaviour of fluid-structure systems
Xing, J.T., Price, W.G., Du, Q.H.
core +1 more source