Results 211 to 220 of about 351,721 (248)
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2016
The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
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The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
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Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures
Journal of Neurophysiology, 2012Absence seizures consist of a brief and sudden impairment of consciousness. They are characterized by bilaterally synchronized spike and wave discharges (SWDs), which reflect abnormal oscillations in the thalamocortical loops. Recent studies have suggested that the basal ganglia are involved in generation of the SWDs, but their roles are poorly ...
Daisuke, Kase +2 more
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The microanatomical environment of the subthalamic nucleus
Journal of Neurosurgery, 2007✓High-frequency stimulation of the subthalamic nucleus (STN) is a widely performed method to treat advanced Parkinson disease. Due to the limitations of current imaging techniques, the 3D microanatomy of the STN and its surrounding structures in the mesencephalon are not well known.
Kim, Rijkers +7 more
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Genetics of subthalamic nucleus in development and disease
Experimental Neurology, 2005The subthalamic nucleus (STN) is a crucial node in the basal ganglia. Clinical success in targeting the STN for deep brain stimulation in Parkinson's disease patients has prompted increased interest in understanding STN biology. In this report, we discuss recent evidence for transcription factor mediated regulation of STN development.
Steven T, Philips +2 more
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Somatotopic Localization in Rhesus Subthalamic Nucleus
Archives of Neurology, 1962In 1947, Mettler and Whittier 1 were able to produce abnormal bodily movements in monkeys by placing lesions in the subthalamic nucleus. These movements, occurring for the most part in the limbs, closely resembled those seen in ballism (flinging movements) or, more broadly, chorea ("dancing" movements).
F A, METTLER, G M, STERN
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The Subthalamic Nucleus and Tremor in Parkinson's Disease
Movement Disorders, 2008The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor.
M C, Rodriguez +7 more
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Neuroscience Letters, 2009
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an effective treatment of idiopathic Parkinson disease (PD). Exactly how HFS works remains unclear. Although HFS of the STN is most effective in improving contralateral motor functions, clinical studies have shown bilateral beneficial effects suggesting that unilateral STN HFS affects
Peter, Novak +5 more
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High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an effective treatment of idiopathic Parkinson disease (PD). Exactly how HFS works remains unclear. Although HFS of the STN is most effective in improving contralateral motor functions, clinical studies have shown bilateral beneficial effects suggesting that unilateral STN HFS affects
Peter, Novak +5 more
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A golgi study on the subthalamic nucleus of the cat
Journal of Comparative Neurology, 1978AbstractThe subthalamic nucleus (ST) of kittens was studied by means of the rapid Golgi silver impregnation method.The neurons of the ST were classified into three types. Type I neurons, the main constituents of the ST, had oval or polygonal cell bodies with a mean diameter of 26 μm by 36 μm and four to six primary dendrites.
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Jules Bernard Luys and the subthalamic nucleus
Movement Disorders, 2002AbstractJules Bernard Luys, a highly energetic French investigator who made important contributions to anatomopathology, clinical neurology, and psychiatry, discovered the subthalamic nucleus in 1865. Unfortunately, Luys’ description of the nucleus that still bears his name, as well as his highly original insights on the role of this important motor ...
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Pain in Parkinson's Disease and the Role of the Subthalamic Nucleus.
Brain, 2021Peter Brown +2 more
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