Results 71 to 80 of about 603,752 (273)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Subtraction terms at NNLO

, 2003
Perturbative calculations at next-to-next-to-leading order for multi-particle final states require a method to cancel infrared singularities. I discuss the subtraction method at NNLO. As a concrete example I consider the leading-colour contributions to e+
A. Gehrmann-De Ridder, C. Anastasiou, C. Anastasiou, D.A. Kosower, D.A. Kosower, D.A. Kosower, D.A. Kosower, E.W.N. Glover, G. Kramer, G. Kramer, J. Collins, J.A.M. Vermaseren, J.M. Campbell, L. Phaf, L.W. Garland, L.W. Garland, S. Catani, S. Catani, S. Catani, S. Catani, S. Catani, S. Catani, S. Catani, S. Catani, S. Dittmaier, S. Frixione, S. Keller, S. Weinzierl, S. Weinzierl, Stefan Weinzierl, T. Gehrmann, T. Matsuura, V. Del Duca, V. Ravindran, W. Giele ., W.T. Giele, Z. Bern, Z. Bern, Z. Bern, Z. Bern, Z. Bern, Z. Bern   +41 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

BRS symmetry for Yang-Mills theory with exact renormalization group

, 1994
In the exact renormalization group (RG) flow in the infrared cutoff $\Lambda$ one needs boundary conditions. In a previous paper on $SU(2)$ Yang-Mills theory we proposed to use the nine physical relevant couplings of the effective action as boundary ...
Akiempong, Akiempong, Akiempong, Alford, Ashmore, Becchi, Becchi, Becchi, Becchi, Bollini, Bollini, Bonini, Bonini, Bonini, Bonini, Breitenlohner, Breitenlohner, Breitenlohner, Butera, Cicuta, Ellwanger, Ellwanger, G. Marchesini, Gallavotti, Girardello, Hooft, Hooft, Hughes, Keller, Keller, M. Bonini, M. D'Attanasio, Marinucci, Morris, Morris, Morris, Polchinski, Reuter, Speer, Tetradis, Warr, Warr, Wetterich, Wilson, Wilson, Wilson, Wilson   +46 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Background subtraction and jet quenching on jet reconstruction

, 2012
In order to assess the ability of jet observables to constrain the characteristics of the medium produced in heavy-ion collisions at the LHC, we investigate the influence of background subtraction and jet quenching on jet reconstruction, with focus on ...
Aad, Abelev, Armesto, Cacciari, Chatrchyan, Chatrchyan, Kodolova, Letícia Cunqueiro, Liliana Apolinário, Néstor Armesto   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Inducing and Enhancing Antimicrobial Activity of Mining-Soil-Derived Actinomycetes Through Component Modification of Bennett’s Culture Medium

Microbiology Research
This study investigated the effect of different culture agar media, derived from Bennett’s medium, on the antimicrobial activity of 15 Streptomyces sp. and 1 Lentzea sp. strains isolated from mining environments. The media were prepared from the standard
Soumia Ait Assou, Jaouad Anissi, Laurent Dufossé, Mireille Fouillaud, Mohammed EL Hassouni   +4 more
doaj   +1 more source

Relation between approximate number system acuity and mathematical achievement: The influence of fluency

Frontiers in Psychology, 2016
Previous studies have observed inconsistent relations between the acuity of the Approximate Number System (ANS) and mathematical achievement. In this paper, we hypothesize that the relation between ANS acuity and mathematical achievement is influenced by
Li Wang, Yuhua Sun, Xinlin Zhou
doaj   +1 more source

Asynchronous Semantic Background Subtraction

Journal of Imaging, 2020
The method of Semantic Background Subtraction (SBS), which combines semantic segmentation and background subtraction, has recently emerged for the task of segmenting moving objects in video sequences.
Anthony Cioppa, Marc Braham, Marc Van Droogenbroeck   +2 more
doaj   +1 more source