α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]
, 2013 The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander +53 more
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Frontiers in Genetics, 2022 The tumor heterogeneity of the transcriptional profiles is independent of genetic variation. Several studies have successfully identified esophageal squamous cell carcinoma (ESCC) subtypes based on the somatic mutation profile and copy number variations ...
Danke Wang +10 more
doaj +1 more source
Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]
, 2013 The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
White, Malcolm F., Zhang, Jing
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Performance of assays for testing antibodies against porcine reproductive and respiratory syndrome virus in sera collected from swine farms in a region with an extreme virus heterogeneity [PDF]
, 2014 Porcine reproductive and respiratory syndrome is the most economically important viral disease in the swine industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) strains are classified into two distinct genotypes, the European ...
Karniychuk, U Uladzimir, Nauwynck, Hans
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Journal of the Formosan Medical Association, 2015 The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis.
Yu-Ting Lin +9 more
doaj +1 more source
Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env [PDF]
, 2010 Neutralising antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV). However, little is known about the appropriate presentation of neutralisation epitopes in order to induce NAbs ...
Hosie, Margaret J. +6 more
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Wearable sensors system for an improved analysis of freezing of gait in Parkinson's disease using electromyography and inertial signals [PDF]
, 2019 We propose a wearable sensor system for automatic, continuous and ubiquitous analysis of Freezing of Gait (FOG), in patients affected by Parkinson's disease.
Gumiero, Alessandro +5 more
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Frontiers in Pharmacology, 2010 Because of their prominent role in electro-excitability, voltage-gated sodium (NaV) channels have become the foremost important target of animal toxins. These toxins have developed the ability to discriminate between closely related NaV subtypes, making ...
Bert eBillen +4 more
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Subtypes of relapsing-remitting multiple sclerosis identified by network analysis
Frontiers in Digital Health, 2023 We used network analysis to identify subtypes of relapsing-remitting multiple sclerosis subjects based on their cumulative signs and symptoms. The electronic medical records of 113 subjects with relapsing-remitting multiple sclerosis were reviewed, signs
Quentin Howlett-Prieto +5 more
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Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]
, 2019 An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P +9 more
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