Results 91 to 100 of about 962,073 (315)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Discovery and validation of breast cancer subtypes [PDF]

, 2006
Background Previous studies demonstrated breast cancer tumor tissue samples could be classified into different subtypes based upon DNA microarray profiles.
Nicolau, Monica, Bukholm Ida RK, Kapp, Amy V, Dong-Young Noh, Stefanie S Jeffrey, Wonshik Han, Bukholm, Ida R. K., Langerød Anita, Patrick O Brown, Borresen-Dale, Anne-Lise, Jeffrey Stefanie S, Bukholm, Ida R, Anne-Lise Børresen-Dale, Robert Tibshirani, Anita Langerød, Han Wonshik, Langerod, Anita, Nicolau Monica, Han, Wonshik, Tibshirani Robert, Monica Nicolau, Kapp Amy V, Børresen-Dale, Anne-Lise, Brown, Patrick O., Ida RK Bukholm, Noh Dong-Young, Brown Patrick O, Langerød, Anita, Amy V Kapp, Børresen-Dale Anne-Lise, Amy V Kapp, Kapp, Amy V., Tibshirani, Robert, Noh, Dong-Young, Jeffrey, Stefanie S, Brown, Patrick O, Bukholm, Ida R K, Jeffrey, Stefanie S., Bukholm, Ida RK   +38 more
core   +1 more source

Efficient recursive subtyping

Mathematical Structures in Computer Science, 1992
Subtyping in the presence of recursive types for the λ-calculus was studied by Amadio and Cardelli in 1991 (Amadio and Cardelli 1991). In that paper they showed that the problem of deciding whether one recursive type is a subtype of another is decidable in exponential time. In this paper we give an 0(n2) algorithm.
Schwartzbach, Michael Ignatieff, Kozen, Dexter, Palsberg, Jens   +2 more
openaire   +7 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cryptosporidium subtypes.

, 2019
Cryptosporidium subtypes.
Elsa Pavlotzky (2889686), Esther Marva (359426), Julia Vainer (7340540), Yael Glazer (7340543), Avi Peretz (5360486), Tamar Grossman (1962064), Vered Agmon (386623), Shifra Ken-Dror (183100), Lea Valinsky (311306), Orli Sagi (6264701)   +9 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Unusual thymoma subtypes

, 2023
Thymomas are neoplastic proliferations of the epithelial cells of the thymus which are variably admixed with a non-neoplastic lymphoid component. Five common subtypes of thymoma are recognized in the current WHO classification.
den Bakker, Michael A.
core   +1 more source

Inheritance-Based Subtyping

Information and Computation, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kathleen Fisher, John H. Reppy
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source