The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors
Protein Science, Volume 35, Issue 7, July 2026.Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley +1 more source
Protective Efficacy of Subunit Vaccine Expressing Rv0976c Against Tuberculosis. [PDF]
Vaccines (Basel)Zhou Z +10 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Engineered Low-Endotoxin Bacterial Biomimetic Vesicles for Enhanced Oral Dual-Antigen Subunit Vaccine Delivery. [PDF]
J Extracell VesiclesShen X +11 more
europepmc +1 more source
PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses
British Journal of Pharmacology, Volume 183, Issue 13, Page 3619-3632, July 2026.A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath +6 more
wiley +1 more source
Identification and Evaluation of Conserved Subunit Vaccine Candidates Conferring Cross-Serotype Protection Against <i>Streptococcus suis</i> Serotypes 2, 7, 8, and 9. [PDF]
Transbound Emerg DisKang S +5 more
europepmc +1 more source
Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Alejandro Martín‐Toribio +15 more
wiley +1 more source
Optimizing a Subunit Vaccine of <i>Mycobacterium tuberculosis</i> Using In-Silico and In-Vitro Approaches. [PDF]
Iran J Public HealthLing Z, Naeem MA.
europepmc +1 more source
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
Recent Trends in Metabolomics by NMR Spectroscopy
Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco +6 more
wiley +2 more sources