Results 141 to 150 of about 1,747,151 (350)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Prospects for the development of a subunit vaccine against Mycobacterium ulcerans disease (Buruli ulcer) [PDF]

, 2014
Buruli ulcer (BU) is a slow progressing disease of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. It presents in different clinical forms ranging from small non-ulcerative nodules to large ulcers and sometimes multiple ulcerations ...
Bolz, Miriam
core   +1 more source

Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus

bioRxiv, 2018
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a human was transited by a N9 type influenza virus. Effective vaccination against influenza A (H7N9) is a major concern, since it has emerged as a life threatening ...
M. Hasan, P. Ghosh, Kazi Faizul Azim, S. Mukta, Ruhshan Ahmed Abir, J. Nahar, Mohammad Mehedi Hasan Khan   +6 more
semanticscholar   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Enhancement of immune responses to classical swine fever virus E2 in mice by fusion or mixture with the porcine IL-28B

Applied Microbiology and Biotechnology
The E2 subunit vaccine has been considered a promising alternative to an attenuated classical swine fever (CSF) vaccine. However, it fails to induce a good cellular immune response.
Hong Yuan, Yunjuan Jiao, Jie Gao, Tao Wang, Yingju Xia, Kun Li, Yuxuan Yang, Jing Zhang, Huifang Bao, Lihao Wang, Pu Sun, Dong Li, Pinghua Li, Yimei Cao, Zhixun Zhao, Zaixin Liu, Zengjun Lu, Yebing Liu, Xingwen Bai   +18 more
doaj   +1 more source

Circular mRNA-LNP vaccine encoding self-assembled E2-TMD-mi3 nanoparticles licit enhanced CSFV-specific immunity over commercial subunit vaccine

Frontiers in Immunology
The E2 subunit vaccine is crucial for eliminating Classical Swine Fever Virus (CSFV) due to its favorable biosafety and Differentiating Infected from Vaccinated Animals (DIVA) capability.
Chunxi Liu, Weifeng Zhai, Wenhao Nie, Conghao Zhong, Feifei Diao, Bo Yin, Bo Yin, Bo Yin   +7 more
doaj   +1 more source

Designing B‐ and T‐cell multi‐epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection

Journal of Cellular Biochemistry, 2018
The Zika virus is a rapidly spreading Aedes mosquito‐borne sickness, which creates an unanticipated linkage birth deformity and neurological turmoil. This study represents the use of the combinatorial immunoinformatics approach to develop a multiepitope ...
Rajan Kumar Pandey, Rupal Ojha, Amit Mishra, Vijay Kumar Prajapati   +3 more
semanticscholar   +1 more source

Vaccine profile of herpes zoster (HZ/su) subunit vaccine

Expert Review of Vaccines, 2017
Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-related or other causes of decreased T cell ...
Anthony L. Cunningham, Thomas Heineman
openaire   +3 more sources

Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial [PDF]

, 2010
Background: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
van der Werf, Sylvie, Christine Katlama, Annika Vogt, Dominique Costagliola, Katlama, Christine, Sabrina Hadam, Behazine Combadière, Sterry, Wolfram, Vogt, Annika, Costagliola, Dominique, Autran, Brigitte, Blume-Peytav, Ulrike, Brice Mahé, Wolfram Sterry, Bonduelle, Olivia, Shlomo Staszewski, Ulrike Blume-Peytavi, Brigitte Autran, Olivia Bonduelle, Blume-Peytavi, Ulrike, Combadière, Behazine, Mahé, Brice, Hadam, Sabrina, Schaefer, Hans, Staszewski, Shlomo, Hans Schaefer, Sylvie van der Werf   +26 more
core   +2 more sources

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source