Results 201 to 210 of about 1,747,151 (350)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Mosquito Saliva Subunit Vaccine Enhances Efficacy of VLP Vaccines Against Zika and Chikungunya Viruses. [PDF]

Vaccines (Basel)
Jossi S, Cole M, Keskek Turk Y, Verwimp S, Trappeniers K, Luk J, Ang JXD, Alphey L, Delang L, McKimmie CS, Pleguezuelos O.   +10 more
europepmc   +1 more source

Water, water, every where—the advent of hydrated pili structure

The FEBS Journal, EarlyView.
Protein structure is defined by its surrounding water. Naturally, this is also true for the gigantic protein filaments that pathogenic bacteria use to attach to and colonize their host cells. Structures of these filaments for which water can be identified with high confidence have stayed elusive for the longest time.
Hiroya Oki, Hideki Shigematsu, Kazuki Kawahara, Christoph Gerle   +3 more
wiley   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

In silico framework for designing and validating a multi-stage subunit vaccine against Tuberculosis using reverse vaccinology approach. [PDF]

PLoS One
Liaqat A, Dastgir K, Sajjad M, Rehman HM, Akhtar MW.   +4 more
europepmc   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Preclinical immunogenicity and safety evaluation of MDCK cell-derived quadrivalent influenza virus subunit vaccine. [PDF]

Front Immunol
Li S, Lv J, Li X, Yang Y, Yan Y, Sui L, Wu Y.   +6 more
europepmc   +1 more source

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, EarlyView.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

Construction of subunit vaccine by fusing <i>Salmonella</i> flagellin with neutralizing epitopes of porcine epidemic diarrhea virus. [PDF]

Front Vet Sci
Gao X, Rao Y, Jia A, Wang G, Cui J.
europepmc   +1 more source

Safety summary of candidate vaccine, herpes zoster subunit (HZ/su)GRADE of HZ/su

Presentations February 2017 Day 1On the agenda, this presentation listed as: Safety summary of candidate vaccine, herpes zoster subunit (HZ/su)GRADE of HZ/suzoster-02-gsk ...

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