Results 41 to 50 of about 140,048 (213)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimal integration of PV generators and D-STATCOMs into the electrical distribution system to reduce the annual investment and operational cost: A multiverse optimization algorithm and matrix power flow approach

e-Prime: Advances in Electrical Engineering, Electronics and Energy
In this work, we address the problem of optimally integrating photovoltaic distributed generators (PV) and distributed static compensators (D-STATCOMs) in distributed electrical systems (DES).
Luis Fernando Grisales-Noreña, Daniel Sanin-Villa, Oscar Danilo Montoya   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Integration of Distributed Energy Resources in Unbalanced Networks Using a Generalized Normal Distribution Optimizer

Computation
This article proposes an optimization methodology to address the joint placement as well as the capacity design of PV units and D-STATCOMs within unbalanced three-phase distribution systems. The proposed model adopts a mixed-integer nonlinear programming
Laura Sofía Avellaneda-Gómez, Brandon Cortés-Caicedo, Oscar Danilo Montoya, Jesús M. López-Lezama   +3 more
doaj   +1 more source

Time-distance helioseismology: Sensitivity of f-mode travel times to flows

, 2007
Time-distance helioseismology has shown that f-mode travel times contain information about horizontal flows in the Sun. The purpose of this study is to provide a simple interpretation of these travel times.
A. C. Birch, Gizon L., J. Jackiewicz, L. Gizon, T. L. Duvall Jr.   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Linear/Quadratic Programming-Based Optimal Power Flow using Linear Power Flow and Absolute Loss Approximations

, 2017
This paper presents novel methods to approximate the nonlinear AC optimal power flow (OPF) into tractable linear/quadratic programming (LP/QP) based OPF problems that can be used for power system planning and operation.
Demiray, Turhan, Fortenbacher, Philipp
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Optimizing Energy Storage Systems with PSO: Improving Economics and Operations of PMGD—A Chilean Case Study

Applied System Innovation
This work develops a methodology for operating Battery Energy Storage Systems (BESSs) in distribution networks, connected in parallel with a medium- and small-scale photovoltaic Distributed Generator (PMGD), focusing on a real project located in the O ...
Juan Tapia-Aguilera, Luis Fernando Grisales-Noreña, Roberto Eduardo Quintal-Palomo, Oscar Danilo Montoya, Daniel Sanin-Villa   +4 more
doaj   +1 more source

Equilibrium distributions in thermodynamical traffic gas

, 2007
We derive the exact formula for thermal-equilibrium spacing distribution of one-dimensional particle gas with repulsive potential V(r)=r^(-a) (a>0) depending on the distance r between the neighboring particles.
Helbing D Treiber M, Mahnke R Hinkel J Kaupužs J Weber H, May A D, Milan Krbálek, Scharf R   +4 more
core   +1 more source