Results 101 to 110 of about 215,979 (293)

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

The ISME Journal, 2018
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes.
C. Serena, V. Ceperuelo-Mallafré, Noelia Keiran, M. I. Queipo-Ortuño, R. Bernal, R. Gómez-Huelgas, M. Urpí-Sardà, M. Sabater, V. Pérez-Brocal, C. Andrés-Lacueva, A. Moya, F. Tinahones, J. Fernández-Real, J. Vendrell, S. Fernández-Veledo   +14 more
semanticscholar   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Poly(butylene Succinate) (PBS): materials, processing, and industrial applications

Progress in polymer science, 2022
M. Barletta, C. Aversa, Muhammad Ayyoob, A. Gisario, K. Hamad, M. Mehrpouya, H. Vahabi   +6 more
semanticscholar   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella   +3 more
wiley   +1 more source

Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity

Gut Microbes
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. The potential involvement of microbiota-mediated intestinal immunity and related signals in metformin ...
Ying Zhang, Aiting Wang, Wei Zhao, Jia’an Qin, Yu Zhang, Bing Liu, Chengcheng Yao, Jianglan Long, Mingxia Yuan, Dan Yan   +9 more
doaj   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice

Cell Reports Medicine
Summary: This study evaluates the efficacy of the postbiotic Probio-Eco in alleviating constipation in humans and mice. A randomized, double-blind, placebo-controlled crossover trial involving 110 adults with chronic constipation (Rome IV criteria ...
Teng Ma, Yalin Li, Ni Yang, Huan Wang, Xuan Shi, Yanfang Liu, Hao Jin, Lai-Yu Kwok, Zhihong Sun, Heping Zhang   +9 more
doaj   +1 more source

Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis

Frontiers in Immunology, 2016
Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis.
Yi Li, Jia-Yi Zheng, Jian-Qun Liu, Jie Yang, Yang Liu, Chen Wang, Xiao-Nan Ma, Bao-Lin Liu, Gui-Zhong Xin, Li-Fang Liu   +9 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Effects of succinate on growth performance, serum biochemistry and meat quality in Pekin ducks

Italian Journal of Animal Science
This experiment investigated the effects of succinate supplementation on growth performance, serum biochemistry and meat quality in Pekin ducks. A total of 1152 1–d-old female Pekin ducks (50.9 ± 0.2 g) were randomly allocated into 3 treatments with 8 ...
Pinyao Zhao, Inho Kim, Yuanfeng Li, Haitao Li, Jun Liu, Xiang Ao   +5 more
doaj   +1 more source