Results 121 to 130 of about 193,960 (302)
Succinate oxidation by human liver mitochondria [PDF]
, 1965 Factors controlling the rate of oxidation of succinate were studied in mitochondria isolated from twenty-seven specimens of normal human liver obtained at operation.
Henley, Keith S., Laughrey, Earl G.
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Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Advanced Science, EarlyView.The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang +6 more
wiley +1 more source
Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity
AntioxidantsEndothelial dysfunction is a hallmark of several pathological conditions, including cancer, cardiovascular disease and inflammatory disorders. In these conditions, perturbed TCA cycle and subsequent succinate accumulation have been reported.
Reham Atallah +4 more
doaj +1 more source
Advanced Science, EarlyView.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Metoprolol succinate extended release/hydrochlorothiazide combination tablets
, 2007 James W Hainer, Jennifer SuggAstraZeneca LP, Wilmington, DE, USAAbstract: Lowering elevated blood pressure (BP) with drug therapy reduces the risk for catastrophic fatal and nonfatal cardiovascular events such as stroke and myocardial infarction.
Jennifer Sugg, James W Hainer
core
, 2019 [[abstract]]Macrophages form a major cell population in the tumor microenvironment. They can be activated and polarized into tumor-associated macrophages (TAM) by the tumor-derived soluble molecules to promote tumor progression and metastasis.
Wu, JY;Huang, TW;Hsieh, YT;Wang, YF;Yen, CC;Lee, GL;Yeh, CC;Peng, YJ;Kuo, YY;Wen, HT;Lin, HC;Hsiao, CW;Wu, KK;Kung, HJ;Hsu, YJ;Kuo, CC
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Advanced Science, EarlyView.A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li +4 more
wiley +1 more source