Results 131 to 140 of about 193,960 (302)

Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols

Angewandte Chemie, EarlyView.
Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang, Tomoya Ozaki, Bo Li, Shih‐Yuan Liu   +3 more
wiley   +2 more sources

Le récepteur au succinate, cible pharmacologique émergente dans le stress ischémique rénal

Background Succinate is an intermediate of the Krebs cycle that accumulates in Kssues during ischaemia or inflammaKon. Besides its influence on cellular metabolism, the succinate acKvates a G-protein-coupled receptor (SUCNR1).
Szedleski, Alexandre
core   +1 more source

Lewis acidic/Lewis basic character of the bis(triphenyltin) succinate moiety in the hexanuclear complex, [bis(triphenyltin) succinate · 2quinoline N-oxide] · 2[bis(triphenyltin) succinate]*

, 1995
The crystal structure of [bis(triphenyltin) succinate · 2quinoline N-oxide] · 2[bis(triphenyltin) succinate], C138H116N2O14Sn6, (C2/c, a = 23.320(3) Å, b = 12.007(1) Å, c = 42.711(8) Å, β = 92.285(8)°) consists of a hexanuclear molecule whose bis ...

core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Mechanisms of intestinal dysbiosis: new insights into tuft cell functions

Gut Microbes
Symbiosis between the host and intestinal microbial communities is essential for human health. Disruption in this symbiosis is linked to gastrointestinal diseases, including inflammatory bowel diseases, as well as extra-gastrointestinal diseases ...
Nathalie Coutry, Imène Gasmi, Fabien Herbert, Philippe Jay   +3 more
doaj   +1 more source

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

, 2015
The effect of methylmalonate (MMA) on mitochondrial succinate oxidation has received great attention since it could present an important role in energy metabolism impairment in methylmalonic acidaemia.
Schuck, P F, Melo, D R, Melo, DR, Ferreira, GC, Castilho, R F, Mirandola, S R, Castilho, RF, Schuck, PF, Ferreira, G C, Mirandola, SR, Wajner, M   +10 more
core   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Cyclooctanaminium hydrogen succinate monohydrate

, 2012
In the title hydrated salt, C8H18N+·C4H5O4−·H2O, the cyclooctyl ring of the cation is disordered over two positions in a 0.833 (3):0.167 (3) ratio.
Manuel A. Fernandes, Sanaz Khorasani
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source