Results 91 to 100 of about 382,582 (334)

Cancer-derived extracellular succinate: a driver of cancer metastasis

Journal of Biomedical Science, 2022
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in hereditary tumors such as paraganglioma or reduction
Cheng-Chin Kuo, Jing-Yiing Wu, Kenneth K. Wu   +2 more
doaj   +1 more source

Metabolome-guided genomics to identify mutations in isocitrate dehydrogenase, fumarate hydratase and succinate dehydrogenase genes in pheochromocytoma and paraganglioma

Genetics in Medicine, 2018
Metabolic aberrations have been described in neoplasms with pathogenic variants (PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH).
S. Richter, L. Gieldon, Ying Pang, M. Peitzsch, Thanh T. Huynh, R. Letón, Bruna Viana, T. Ercolino, Anastasios Mangelis, E. Rapizzi, M. Menschikowski, D. Aust, M. Kroiss, F. Beuschlein, V. Gudziol, H. Timmers, J. Lenders, M. Mannelli, A. Cascón, K. Pacak, M. Robledo, G. Eisenhofer, B. Klink   +22 more
semanticscholar   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

The Neuroprotective Effects of Curcumin Nanoparticles on The Cerebral Ischemia-Reperfusion Injury in The Rats-The Roles of The Protein Kinase RNA-Like ER Kinase/Extracellular Signal-Regulated Kinase and Transcription Factor EB proteins [PDF]

Cell Journal
Objective: Reduction of cerebral ischemia-reperfusion injury (IRI)/re-oxygenation injury, is defined as the paradoxicalexacerbation of the cellular dysfunction and death, following restoration of the blood flow to previously ischemic tissues.The re ...
Yalda Saghari, Monireh Movahedi, Majid Tebianian, Maliheh Entezari   +3 more
doaj   +1 more source

Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD

Journal of Medical Genetics, 2018
Background Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent causes of inherited phaeochromocytomas/paragangliomas. Insufficient information regarding penetrance and phenotypic variability hinders optimum management of mutation ...
K. Andrews, D. Ascher, Douglas E. V. Pires, D. Barnes, L. Vialard, R. Casey, N. Bradshaw, J. Adlard, S. Aylwin, P. Brennan, C. Brewer, T. Cole, J. Cook, R. Davidson, A. Donaldson, A. Fryer, L. Greenhalgh, S. Hodgson, R. Irving, F. Lalloo, M. McConachie, V. Mcconnell, P. Morrison, V. Murday, Soo-Mi Park, H. Simpson, K. Snape, S. Stewart, S. Tomkins, Y. Wallis, L. Izatt, D. Goudie, R. Lindsay, C. Perry, E. Woodward, A. Antoniou, E. Maher   +36 more
semanticscholar   +1 more source

Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties

Chemistry &Biodiversity, EarlyView.
ABSTRACT Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG‐63 cells.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Mariana Reis, Rhuana V. Médice, Janaína Morone, Raquel Silva, João Morais, Vitor Vasconcelos, Agenor Valadares Santos   +8 more
wiley   +1 more source

LIGHT INFLUENCE ON SUCCINATE DEHYDROGENASE ACTIVITY IN MAIZE LEAVES [PDF]

Journal of Stress Physiology & Biochemistry, 2005
Photosynthesis and respiration participates in energy production by plants undo different light conditions. It looks quite important to provide a balanced regulation of these processes. It was show in presented study that succinate dehydrogenase activity
Popov V.N., Eprintsev A.T., Fedorin D.N., Leonova Yu.A.   +3 more
doaj  

SDHB and SDHA Immunohistochemistry in Canine Pheochromocytomas

Animals, 2020
Pheochromocytomas (PCs) are tumors arising from the chromaffin cells of the adrenal glands and are the most common tumors of the adrenal medulla in animals. In people, these are highly correlated to inherited gene mutations in the succinate dehydrogenase
Firas M. Abed, Melissa A. Brown, Omar A. Al-Mahmood, Michael J. Dark   +3 more
doaj   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Carbon Energy, EarlyView.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen   +3 more
wiley   +1 more source

Improvement of succinate production from methane by combining rational engineering and laboratory evolution in Methylomonas sp. DH-1

Microbial Cell Factories
Recently, methane has been considered a next-generation carbon feedstock due to its abundance and it is main component of shale gas and biogas. Methylomonas sp. DH-1 has been evaluated as a promising industrial bio-catalyst candidate.
Jae-Hwan Jo, Jeong-Ho Park, Byung Kwon Kim, Seon Jeong Kim, Chan Mi Park, Chang Keun Kang, Yong Jun Choi, Hyejin Kim, Eun Yeol Lee, Myounghoon Moon, Gwon Woo Park, Sangmin Lee, Soo Youn Lee, Jin-Suk Lee, Won-Heong Lee, Jeong-Il Kim, Min-Sik Kim   +16 more
doaj   +1 more source