Results 81 to 90 of about 67,725 (262)

Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications

Frontiers in Immunology
Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation. Recent studies have revealed that immune metabolites, particularly succinate, play a critical role in its pathogenesis.
Yi Fan, Naidi Wang, Chenxu Zhao, Zhaoqi Zhang   +3 more
doaj   +1 more source

Determining frequencies of fungicide resistance in Leptosphaeria maculans that render demethylation inhibitor fungicides ineffective in the field

Pest Management Science, EarlyView.
As little as 1–10% of the population is needed to be resistant for demethylation inhibitor fungicides to be rendered ineffective. Following a single round of selection, the frequency increases by more than 15% with limited fitness penalty detected when no selection is present.
Alec J McCallum, Alexander Idnurm, Stephen J Marcroft, Andrew H Ware, Elizabeth M Sheedy, Angela P Van de Wouw   +5 more
wiley   +1 more source

The epidemiology of the blackleg pathogen, Leptosphaeria maculans, impacts fungicide resistance management strategies

Pest Management Science, EarlyView.
Understanding how infection timing drives disease is essential for the development of fungicide resistance management strategies. For blackleg disease of canola, all infection timings can contribute to the following generation, therefore all fungicide applications have the ability to select for resistance.
Alec J McCallum, Sean Roberts, Alexander Idnurm, Angela P Van de Wouw   +3 more
wiley   +1 more source

Disease control in oilseed rape: Current insights and perspectives for next‐generation integrated pest management

Pest Management Science, EarlyView.
Winter oilseed rape in Europe suffers frequent pathogen losses. This review outlines key integrated pest management (IPM) strategies, rotation, residue and tillage management, optimized sowing, resistance, and targeted fungicides supported by forecasting.
Jon S West, Małgorzata Jędryczka, Nazanin Zamani‐Noor   +2 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study

Environmental Toxicology, EarlyView.
ABSTRACT A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil.
Sidney Fernandes Sales Junior, Amanda Pontes Lopes, Heloíse Martins de Souza, Regina Fonseca, Enrico Mendes Saggioro, Francielli Monteiro Casanova, Kamila Cezar Gramlich, Tatiana Dillenburg Saint'Pierre, Carlos German Massone, Renato Carreira, Rachel Ann Hauser‐Davis   +10 more
wiley   +1 more source

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

Environmental Toxicology, EarlyView.
ABSTRACT Fluopyram is a next‐generation fungicide widely used in agriculture; however, its persistence in soils and mobility toward aquatic systems have raised concerns regarding potential ecotoxicological risks. This study evaluated the cytogenotoxic effects of a commercial fluopyram‐based pesticide formulation on Allium cepa root meristem cells ...
Carlos Filipe Camilo‐Cotrim, Natanael Alves da Silva, Gabriela Gomes Lima, Igor Rodrigues Vasconcelos, Luciana Souza Ondei, Elisa Flávia Luiz Cardoso Bailão, Antônio Sérgio Nakao de Aguiar, Marcelino Benvindo‐Souza, Leonardo Luiz Borges, Virgínia Damin, Luciane Madureira Almeida   +10 more
wiley   +1 more source

Phosphoethanolamine: a translational journey from biological process and physiopathological effects to therapeutical innovation - a mini-review

Frontiers in Pharmacology
Phosphoethanolamine (pETN), an endogenous metabolite in the Kennedy pathway for membrane phospholipid synthesis, can be chemically synthesized and exemplifies translational pharmacology through its journey from basic biochemistry to clinical application.
Guilherme Ayres Rossini, Guilherme Ayres Rossini, Guilherme Ayres Rossini, Marcia Koike, Denise F. Barbeiro, Hermes Barbeiro, Daniel Rabelo, Francisco Garcia Soriano, Marcel Cerqueira Cesar Machado, Durvanei Augusto Maria, Durvanei Augusto Maria   +10 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Whole‐Genome Sequencing and Resequencing of Hucho bleekeri Provides Insights into Genetic Mechanisms of Environmental Adaptation

Integrative Zoology, EarlyView.
A high‐quality chromosome‐level reference genome was constructed for Hucho bleekeri. Population structure and environmental adaptation of Hucho species were revealed by whole‐genome resequencing. ABSTRACT Salmonidae represents an important family in the study of genome evolution following genome duplication.
Yeyu Chen, Huanchao Yang, Zhao Liu, Xiaoyun Wu, Qinyao Wei, Yanling Chen, Jue Lin, Yi Yu, Quanyu Tu, Hua Li   +9 more
wiley   +1 more source