Results 71 to 80 of about 11,995 (215)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

, 2016
The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There has been increasing evidence in recent years that maleimide-based ADCs are prone to payload loss via a retro-Michael type ...
Eric Sousa (1735579), Tracey Clark (1735588), Jeff Casavant (1735585), Frank Loganzo (1698205), Manoj Charati (1735576), Tao He (23919), Edmund I. Graziani (1735573), Dangshe Ma (1735570), L. Nathan Tumey (1735582), Judy Lucas (1480975), Xiaogang Han (1419184), Frank Barletta (1735567)   +11 more
core   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Inhibition of Succinimide Formation in Aqueous Zn-rHirudin Suspensions1 [PDF]

, 2018
Purpose. The formation of succinimide intermediates at Asp-Gly sites and their hydrolysis products, e.g., isoAsp isomers, represents a common source of microheterogeneity in therapeutic proteins.
Gietz, Ursula, Arvinte, Tudor, Alder, Ruth, Merkle, Hans   +3 more
core  

Racemization of succinimide.

, 2013
Figure 6a: increase of D-Asp with racemization of L-suc peptide at 37°C. Figure 6b: increase of L-Asp with racemization of D-suc peptide at 37°C. We calculated the rate constant for racemization of succinimide at 37°C (k9 and k10) by using fitted curves ...
Kenzo Aki (386666), Norihiko Fujii (386667), Noriko Fujii (153802)   +2 more
core   +1 more source

Metal‐Catalyzed Benzannulation: Recent Advances in Catalyst Design, Mechanistic Insights, and Aromatic Framework Construction

The Chemical Record, EarlyView.
This review offers a contemporary overview of metal‐catalyzed benzannulation (2018–present) encompassing transition, main‐group, post‐transition, and rare‐earth‐metal catalysts. It systematically highlights catalyst design, mechanistic insights, stereo‐ and regioselectivity, and synthetic applications toward aromatic and heteroaromatic scaffolds, while
Sana Jamshaid, Divya Shrestha, Raju S. Thombal, Jeung Gon Kim, Kim Seong Cheol, Yong Rok Lee   +5 more
wiley   +1 more source

Three-Component Tandem Amidosulfenylation of Alkenes for the Synthesis of β‑Succinimide Sulfides

, 2023
An environmentally benign multicomponent strategy for the amidosulfenylation of alkenes for the synthesis of β-succinimide sulfides is disclosed. In this process, common disulfides smoothly act as a sulfur-based source, and N-iodosuccinimide (NIS) is ...
Wenjian Li, Wenjian Li (401052), Guo-Jun Deng, Fuhong Xiao, Lin Yao (332529), Fuhong Xiao (1470838), Guo-Jun Deng (1427659), Lin Yao   +7 more
core   +1 more source

New approaches to the synthesis of substituted derivatives of the [B₃H₈]⁻ anion

Тонкие химические технологии
Objectives. To develop methods for the synthesis of substituted derivatives of the octahydrotriborate anion. Such compounds can be considered as hydrogen storage, components of ionic liquids, precursors for the production of boride coatings using the ...
A. A. Lukoshkova, A. T. Shulyak, E. E. Posypayko, N. A. Selivanov, A. V. Golubev, А. S. Kubasov, A. Yu. Bykov, A. P. Zhdanov, K. Yu. Zhizhin, N. T. Kuznetsov   +9 more
doaj   +1 more source

DNA‐Barcoded Polysaccharide Specific Monoclonal Antibodies Facilitate Sensitive and Multiplexed Detection of Cell Wall Polymers

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant cell walls are polysaccharide‐rich extracellular matrices composed of multiple complex carbohydrate polymer networks, including cellulose, hemicelluloses, pectins, and glycosylated proteins. Polysaccharide deposition critically impacts cell wall structure, and structural microheterogeneity within cell wall glycans also influences polymer
C. Frankie Griffith, Michael G. Hahn, Ian S. Wallace   +2 more
wiley   +1 more source

AE succinimide, an analogue of Methyllycaconitine, when bound generates a nonconducting conformation of the α4β2 nicotinic acetylcholine receptor

, 2020
Nicotinic acetylcholine (nACh) receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission. The α4β2 nACh receptor is highly expressed in the brain and exists in two functional stoichiometries: the (α4)2(β2)3 and (α4)3(β2)2
Chebib, Mary C., Halliday, Jill I., Absalom, Nathan L. (R20537), Quek, Gracia X., Indurthi, Dinesh C., Qudah, Taima, Karim, Nasiara, McLeod, Malcolm D.   +7 more
core   +1 more source