Results 141 to 150 of about 1,764 (178)
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Determination of Urinary Succinylacetone by Capillary Gas Chromatography
Journal of Chromatographic Science, 1984The average analytical recovery of succinylacetone added to urine and separated by capillary gas chromatography was 69% for solvent extraction and 72% for anion exchange separation. Treating succinylacetone with hydroxylamine hydrochloride at a pH of less than 5 caused formation of a derivative separated by capillary gas chromatography into two isomers:
M, Tuchman +5 more
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Neurotoxic aspects of porphyrinopathies: Lead and succinylacetone
Environmental Research, 1982Abstract Neurotoxic effects of heavy metals and polyhalogenated hydrocarbons frequently occur at low levels of exposure, in some cases below those levels where direct toxic actions of these compounds have been demonstrated. Since alterations in heme synthesis are effects common to many of these compounds, the potential role of altered heme synthesis ...
E K, Silbergeld +4 more
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Synthesis and immunosuppressive activity of novel succinylacetone analogues
Archives of Pharmacal Research, 2003This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for ...
Taek Hyeon, Kim +3 more
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Prenatal diagnosis of hereditary tyrosinaemia: Measurement of succinylacetone in amniotic fluid
Prenatal Diagnosis, 1982AbstractA method is proposed for prenatal diagnosis in pregnancies at risk of hereditary tryosinaemia. Affected fetuses were detected on the basis of the abnormal presence in the amniotic fluid of succinylacetone, a metabolite previously identified in sera and urines of patients suffering from hereditary tyrosinaemia.
R, Gagné +5 more
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Treatment of experimental autoimmune uveitis in the rat with systemic succinylacetone
Clinical Immunology and Immunopathology, 1988The effects of succinylacetone (SA) on the development of S-antigen-induced experimental autoimmune uveitis (EAU) in the rat were studied. SA totally suppressed EAU at Day 14 when animals were treated with a constant infusion of 1.80 mg/hr by an osmotic minipump. Three intervals of treatment with this dose rate were used (Day 0-7, Day 7-14, or Day 0-14)
S A, Skolik +4 more
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A GC/MS method for determination of succinylacetone in Arabidopsis thaliana
Analytical and Bioanalytical Chemistry, 2016Succinylacetone was known to be a toxic metabolite of tyrosine in human and animals caused by blockage of the final step in tyrosine degradation pathway, but its existence in plant was unclear though the metabolic disturbance of tyrosine was also found in plant.
Lizi, Zhou +6 more
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Effects of succinylacetone on growth and respiration of L1210 leukemia cells
Cancer Letters, 19854,6-Dioxoheptanoic acid (succinylacetone, SA), a potent inhibitor of heme biosynthesis, suppressed growth and decreased respiration of L1210 leukemia cells in vitro. Growth of cells incubated in the presence of 2--4 mM SA for the first 2 days declined, and after 3 days virtually ceased.
E C, Weinbach, P S, Ebert
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Urinary Succinylacetone Analysis by Gas Chromatography-Mass Spectrometry (GC-MS)
2016Succinylacetone (SA) is used for the diagnosis and monitoring of patients with tyrosinemia type I (Tyr I). SA is exclusively elevated in blood and urine of patients with Tyr I. As urinary SA concentration is much higher than blood, SA is usually tested in urine samples.
Hongjie, Chen, Chunli, Yu
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Effects of succinylacetone on amino acid uptake in the rat kidney
Biochemical Medicine and Metabolic Biology, 1987Infants with hereditary tyrosinemia also have a renal Fanconi syndrome and excrete succinylacetone (SA). We have studied the effects of SA on rat renal tubular amino acid transport in vivo and in vitro using isolated renal tubules. Injection of SA produces increased clearance of several amino acids in the intact animal.
P D, Spencer, K S, Roth
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