Results 111 to 120 of about 4,329 (141)

Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells

Journal of Molecular Catalysis B: Enzymatic, 2013
Abstract Bioconversion of sucralose-6-acetate to sucralose, an artificial sweetener has been carried out using Arthrobacter sp. (ABL) and Bacillus subtilis (RRL-1789) strains isolated at IIIM, Jammu, India. Biotransformation of sucralose-6-acetate to sucralose involves use of microbial whole cells, immobilized whole cells and immobilized whole ...
Asha Chaubey, Chand Raina, Rajinder Parshad, Abdul Rouf, Pankaj Gupta, Subhash C. Taneja   +5 more
openaire   +1 more source

The absence of genotoxicity of sucralose

Food and Chemical Toxicology, 2010
Sucralose is a non-nutritive sweetener that is approximately 600 times sweeter than table sugar. It is currently approved for use in over 80 countries. Evidence from chronic studies demonstrates that this compound is not carcinogenic. This report summarizes the results of genotoxicity studies that were part of the original safety assessment of ...
D, Brusick, V L, Grotz, R, Slesinski, C L, Kruger, A W, Hayes   +4 more
openaire   +2 more sources

Sucralose metabolism and pharmacokinetics in man

Food and Chemical Toxicology, 2000
The metabolic and pharmacokinetic profile of sucralose was studied in human volunteers. Following a single oral dose of (14)C-sucralose (1mg/kg, 100 microCi) to eight male subjects, a mean of 14.5% (range 8.9 to 21.8%) of the radioactivity was excreted in urine and 78.3% (range 69.4 to 89.6%) in the faeces, within 5 days.
A, Roberts, A G, Renwick, J, Sims, D J, Snodin   +3 more
openaire   +2 more sources

The metabolic fate of sucralose in rats

Food and Chemical Toxicology, 2000
The fate of sucralose was investigated in rats following single intravenous or oral doses of 2-1000mg/kg. Following intravenous administration (2-20mg/kg) approximately 80% of the dose was eliminated in urine with 9-16% in the faeces. In contrast, only about 5% of oral doses (10-1000mg/kg) was recovered in the urine, indicating that sucralose is poorly
J, Sims, A, Roberts, J W, Daniel, A G, Renwick   +3 more
openaire   +2 more sources

Hydrophobic interactions of sucralose with protein structures

Archives of Biochemistry and Biophysics, 2018
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress.
Nimesh Shukla, Enrico Pomarico, Cody J.S. Hecht, Erika A. Taylor, Majed Chergui, Christina M. Othon   +5 more
openaire   +2 more sources

Acute and subchronic toxicity of sucralose

Food and Chemical Toxicology, 2000
The toxicity of sucralose has been evaluated in acute and subchronic toxicity studies. Acute oral toxicity studies in male and female mice and male rats documented no deaths or treatment-related signs at doses of 16g/kg for mice and 10g/kg for rats. Sucralose was administered to male and female rats for 4 and 8 weeks at dietary concentrations of 1.0, 2.
openaire   +2 more sources

An overview of the safety of sucralose

Regulatory Toxicology and Pharmacology, 2009
Sucralose is a non-nutritive sweetener used in a broad range of foods and beverages and is the non-nutritive sweetener in retail SPLENDA Sweetening Products, composed of sucralose and common food ingredients. A review of the extensive body of evidence that supports the safety of sucralose is provided. The results of an independent review of a new study
V Lee, Grotz, Ian C, Munro
openaire   +2 more sources

Popular Sweetner Sucralose as a Migraine Trigger

Headache: The Journal of Head and Face Pain, 2006
Sucralose (trichlorogalactosucrose, or better known as Splenda) is an artificial sweetener from native sucrose that was approved by the FDA on April 1, 1998 (April Fool's Day). This observation of a potential causal relationship between sucralose and migraines may be important for physicians to remember this can be a possible trigger during dietary ...
Rajendrakumar M, Patel, Rakesh, Sarma, Edwin, Grimsley   +2 more
openaire   +2 more sources

TCORS- Sucralose data

2017
DATA
openaire   +1 more source

Migraine Triggered by Sucralose—A Case Report

Headache: The Journal of Head and Face Pain, 2006
Sucralose is the active compound of the most commonly sold sweetener in the United States. Different than aspartame, sucralose is not considered to be a migraine trigger. Herein we report a patient with attacks of migraine consistently triggered by sucralose.
Marcelo E, Bigal, Abouch V, Krymchantowski   +1 more
openaire   +2 more sources