Results 151 to 160 of about 9,709 (198)

Sucralose Consumption Ablates Cancer Immunotherapy Response through Microbiome Disruption

Cancer Discovery
Studying preclinical models and human patients with cancer treated with immune checkpoint blockade reveals that sucralose alters gut microbiota, impeding T-cell function and reducing immunotherapeutic efficacy.
Kristin M Morder, Madison Nguyen, Drew Wilfahrt, Zakaria L. Dahmani, A. Burr, Bingxian Xie, Michael Morikone, Hector M Nieves-Rosado, William G Gunn, Drew E Hurd, Hong Wang, S. Mullett, Kaitlin Bossong, S. Gelhaus, D. Rajasundaram, Lawrence P. Kane, Greg M. Delgoffe, Jishnu Das, D. Davar, A. Overacre-Delgoffe   +19 more
semanticscholar   +1 more source

Imprinted carbon dots electrochemical sensor for ultrasensitive and selective detection of sucralose in real samples

Materials Chemistry Frontiers
One of the most widely used artificial non-nutritive sweeteners in food is sucralose (SC) which provides sweetness with few or no calories.
Asmaa Mansour, Wael I. Mortada, Wael I. Mortada, F. Awad, A. F. S. Molouk, Magdi E. Khalifa, A. Abdallah   +6 more
semanticscholar   +1 more source

The absence of genotoxicity of sucralose

Food and Chemical Toxicology, 2010
Sucralose is a non-nutritive sweetener that is approximately 600 times sweeter than table sugar. It is currently approved for use in over 80 countries. Evidence from chronic studies demonstrates that this compound is not carcinogenic. This report summarizes the results of genotoxicity studies that were part of the original safety assessment of ...
D, Brusick, V L, Grotz, R, Slesinski, C L, Kruger, A W, Hayes   +4 more
openaire   +2 more sources

Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.

Environmental Health Perspectives
BACKGROUND The impact of non-nutritive sweeteners on male reproductive health, particularly at the cellular level, remains insufficiently explored. Sucralose's high stability and resistance to degradation during wastewater treatment raises concerns about
Yi-Fen Chiang, Yang-Ching Chen, Ko-Chieh Huang, Mohamed Ali, S. Hsia   +4 more
semanticscholar   +1 more source

Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2023
Sucralose and acesulfame-potassium consumption alters gut microbiota in rodents, with unclear effects in humans. We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 (n = 17) or 8 (n = 8 ...
A. Sylvetsky, Rebecca A Clement, Nathaniel Stearrett, Najy T Issa, Fiona J Dore, Raja Mazumder, Charles Hadley King, Monica J Hubal, Peter J. Walter, Hongyi Cai, Sabyasachi Sen, Kristina I. Rother, Keith A. Crandall   +12 more
semanticscholar   +1 more source

Sucralose metabolism and pharmacokinetics in man

Food and Chemical Toxicology, 2000
The metabolic and pharmacokinetic profile of sucralose was studied in human volunteers. Following a single oral dose of (14)C-sucralose (1mg/kg, 100 microCi) to eight male subjects, a mean of 14.5% (range 8.9 to 21.8%) of the radioactivity was excreted in urine and 78.3% (range 69.4 to 89.6%) in the faeces, within 5 days.
A, Roberts, A G, Renwick, J, Sims, D J, Snodin   +3 more
openaire   +2 more sources

Sucralose: A Review of Environmental, Oxidative and Genomic Stress

Nutrients
This review explores current knowledge on the environmental, oxidative, and genomic effects of sucralose (E955), an artificial sweetener widely used in food products, including those for children, and known to cross both the placental barrier and into ...
V. Tkach, Tetiana V. Morozova, I. Gaivão, N. Miranda, Y. Ivanushko, José Inácio Ferrão de Paiva Martins, A. Barros   +6 more
semanticscholar   +1 more source

Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3.

The Journal of the Science of Food and Agriculture, 2023
BACKGROUND Non-nutritive sweeteners (such as sucralose) bind to sweet receptors Tas1r2/Tas1r3 on intestinal endocrine L cells after diets to up-regulate blood glucose. However, the mechanism by which sucralose regulates postprandial blood glucose has not
Qing Shi, Lei Xu, Lei Cai, Shao-ping Deng, Xiangyang Qi   +4 more
semanticscholar   +1 more source

Biological and Behavioral Responses of Drosophila melanogaster to Dietary Sugar and Sucralose

International Journal of Molecular Sciences
Sugar and sucralose are frequently used together and separately in human food and beverages, which is the reason why studying their biological action on different organisms is really important.
N. Miranda, V. Tkach, A. Barros, A. Martins-Bessa, I. Gaivão   +4 more
semanticscholar   +1 more source

Effect of Sucralose Intake on Human and Mouse/Rat Gut Microbiota Composition: A Systematic Review and Meta-Analysis

Food reviews international (Print), 2023
Introduction Sucralose is a popular nonnutritive sweetener. The association of sucralose with gut microbiota and its effect on body weight remains unclear; therefore, we examined the effect of sucralose on human and mouse/rat gut microbiota composition ...
Chung-Yu Chen, Cheng-Hao Tien, Yue-Hwa Chen, Daniel Garrido, A. Farzi, H. Herzog, Hsien-Yu Fan, Y. Chen   +7 more
semanticscholar   +1 more source