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The absence of genotoxicity of sucralose
Food and Chemical Toxicology, 2010Sucralose is a non-nutritive sweetener that is approximately 600 times sweeter than table sugar. It is currently approved for use in over 80 countries. Evidence from chronic studies demonstrates that this compound is not carcinogenic. This report summarizes the results of genotoxicity studies that were part of the original safety assessment of ...
D, Brusick +4 more
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The metabolic fate of sucralose in rats
Food and Chemical Toxicology, 2000The fate of sucralose was investigated in rats following single intravenous or oral doses of 2-1000mg/kg. Following intravenous administration (2-20mg/kg) approximately 80% of the dose was eliminated in urine with 9-16% in the faeces. In contrast, only about 5% of oral doses (10-1000mg/kg) was recovered in the urine, indicating that sucralose is poorly
J, Sims +3 more
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The pharmacokinetics and metabolism of sucralose in the mouse
Food and Chemical Toxicology, 2000The excretion and metabolism of (14)C-sucralose has been investigated in mice following intravenous and oral administration. A 20mg/kg intravenous dose was rapidly excreted mainly in the urine (80% in 5 days). After 100, 1500 and 3000mg/kg oral doses of (14)C-sucralose, means of 23%, 15% and 16% of the dose, respectively, were excreted in the urine ...
B A, John, S G, Wood, D R, Hawkins
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The pharmacokinetics and metabolism of sucralose in the rabbit
Food and Chemical Toxicology, 2000The excretion and metabolism of (14)C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days.
B A, John, S G, Wood, D R, Hawkins
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Proceedings of 2022 AOCS Annual Meeting & Expo, 2022
Sucralose differs from sucrose only by virtue of having three Cl groups instead of OH groups. Its intriguing features include being noncaloric, noncariogenic, 600 times sweeter than sucrose, stable at high temperatures/acidic pH's, and void of disagreeable aftertastes.
Malick Samateh +4 more
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Sucralose differs from sucrose only by virtue of having three Cl groups instead of OH groups. Its intriguing features include being noncaloric, noncariogenic, 600 times sweeter than sucrose, stable at high temperatures/acidic pH's, and void of disagreeable aftertastes.
Malick Samateh +4 more
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Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells
Journal of Molecular Catalysis B: Enzymatic, 2013Abstract Bioconversion of sucralose-6-acetate to sucralose, an artificial sweetener has been carried out using Arthrobacter sp. (ABL) and Bacillus subtilis (RRL-1789) strains isolated at IIIM, Jammu, India. Biotransformation of sucralose-6-acetate to sucralose involves use of microbial whole cells, immobilized whole cells and immobilized whole ...
Asha Chaubey +5 more
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Acute and subchronic toxicity of sucralose
Food and Chemical Toxicology, 2000The toxicity of sucralose has been evaluated in acute and subchronic toxicity studies. Acute oral toxicity studies in male and female mice and male rats documented no deaths or treatment-related signs at doses of 16g/kg for mice and 10g/kg for rats. Sucralose was administered to male and female rats for 4 and 8 weeks at dietary concentrations of 1.0, 2.
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Analytical Methodologies for the Detection of Sucralose in Water
Analytical Chemistry, 2013A detailed evaluation of two liquid chromatography-mass spectrometry techniques, quadrupole time-of-flight mass spectrometry (LC/Q-TOF-MS) and triple quadrupole mass spectrometry (LC/MS-MS), was carried out in terms of sensitivity, selectivity, and ionization mode for the detection of sucralose in environmental water samples, which is an important ...
Imma, Ferrer +2 more
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Popular Sweetner Sucralose as a Migraine Trigger
Headache: The Journal of Head and Face Pain, 2006Sucralose (trichlorogalactosucrose, or better known as Splenda) is an artificial sweetener from native sucrose that was approved by the FDA on April 1, 1998 (April Fool's Day). This observation of a potential causal relationship between sucralose and migraines may be important for physicians to remember this can be a possible trigger during dietary ...
Rajendrakumar M, Patel +2 more
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Hydrophobic interactions of sucralose with protein structures
Archives of Biochemistry and Biophysics, 2018Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress.
Nimesh Shukla +5 more
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