Results 191 to 200 of about 158,744 (300)

Agreement of the performance of equine electrocardiogram recording devices for ECG complexity analysis

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Non‐linear equine electrocardiography (ECG) analysis is an actively developing study area which has the potential to lead to novel, artificial intelligence‐based diagnostic tools in equine cardiology. As more ECG recording devices are becoming available, there is a need to ensure results are interchangeable regardless of the ...
Vadim Alexeenko   +6 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

open access: yesThe FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy   +7 more
wiley   +1 more source

Prospective use of genomics in the evaluation of sudden cardiac death: results from a national health service population pathway. [PDF]

open access: yesEBioMedicine
Wade C   +17 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang   +9 more
wiley   +1 more source

Relatives' Experiences of Circulatory Death Following Out‐of‐Hospital Cardiac Arrest and Their Hypothetical Perspectives on Organ Donation: A Qualitative Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore relatives' experiences of the circulatory death of a family member following out‐of‐hospital cardiac arrest and to explore their hypothetical perspectives on being asked to decide about organ donation in this situation. This study forms part of a broader initiative undertaken to assess the prerequisites for implementing ...
Gisela Vogel   +3 more
wiley   +1 more source

Diagnostic relevance of angiography-derived coronary microcirculatory resistance in sudden cardiac death. [PDF]

open access: yesQuant Imaging Med Surg
Sedoud B   +11 more
europepmc   +1 more source

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