Results 41 to 50 of about 4,113 (218)
Seizure Clusters, Seizure Severity Markers, and SUDEP Risk
Frontiers in Neurology, 2021 Rationale: Seizure clusters may be related to Sudden Unexpected Death in Epilepsy (SUDEP). Two or more generalized convulsive seizures (GCS) were captured during video electroencephalography in 7/11 (64%) patients with monitored SUDEP in the MORTEMUS ...
Manuela Ochoa-Urrea +51 more
doaj +1 more source
Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures
Annals of Neurology, EarlyView.Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Haley E. Pysick +9 more
wiley +1 more source
Trend of Sudden Unexpected Death in Epilepsy Incidence Rate in Rural West China
Frontiers in Neurology, 2021 Objectives: To explore the trend of sudden unexpected death in epilepsy (SUDEP) incidence rate over time in rural west China.Methods: We scanned probable SUDEP patients from the epilepsy program between 2010 and 2019 in rural West China and performed a ...
Haijiao Wang +5 more
doaj +1 more source
SUDEP, the aftermath: supporting the bereaved [PDF]
Practical Neurology, 2017 Sudden unexpected death in epilepsy is a recurring calamity, yet there is little evidence to guide standards of care for supporting the bereaved. Grief in bereavement includes loss, feelings of guilt, anger and blame. There is also the shock and trauma of the sudden event. How can this be alleviated?
Nashef, Lina, Leach, John Paul
openaire +2 more sources
Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy
Epilepsia, EarlyView.Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis +7 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens +8 more
wiley +1 more source
A clinical and pathological study in patients with sudden unexpected death in Epilepsy
Acta Epileptologica, 2019 Background Sudden unexpected death of epilepsy (SUDEP) is a severe outcome of epilepsy. This study aimed to report the clinical and pathological findings in patients with SUDEP. Methods The record of patients with sudden death was screened.
Weihua Yu +5 more
doaj +1 more source
Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP
Frontiers in Neurology, 2023 Epilepsy is a chronic neurological disease characterized by abnormal brain activity, which results in repeated spontaneous seizures. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related premature death, particularly in drug-
Francesca Bosco +11 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective This study aimed to evaluate the real‐world performance of a wrist‐worn seizure detection device for timely clinical interventions within an epilepsy monitoring unit (EMU). Methods We conducted a prospective observational study involving patients admitted to the EMU at a tertiary care center.
Amirhossein Jahani +9 more
wiley +1 more source