Results 71 to 80 of about 5,831 (244)

Regional microglial populations in central autonomic brain regions in SUDEP

Epilepsia, 2021
Sudden unexpected death in epilepsy (SUDEP) may arise as a result of autonomic dysfunction during a seizure. The central autonomic networks (CANs) modulate brainstem cardiorespiratory regulation.
Alyma Somani, Hanna El-Hachami, S. Patodia, S. Sisodiya, M. Thom   +4 more
semanticscholar   +1 more source

The upside of epilepsy: Theories of an evolutionary paradox

Epilepsia Open, EarlyView.
Abstract The persistence of common, heritable conditions, like epilepsy, that are associated with reduced reproductive fitness is an evolutionary paradox. Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises.
Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp   +3 more
wiley   +1 more source

SUDEP kompakt – praxisrelevante Erkenntnisse und Empfehlungen zum plötzlichen, unerwarteten Tod bei Epilepsie

Der Nervenarzt, 2021
„Sudden unexpected death in epilepsy“ (SUDEP) ist der plötzliche, unerwartete Tod eines Epilepsiepatienten, der unter „gutartigen“ Umständen und ohne typische Todesursachen auftritt. SUDEP betrifft alle Epilepsiepatienten.
R. Surges, Stefan Conrad, H. Hamer, A. Schulze-Bonhage, A. Staack, B. Steinhoff, A. Strzelczyk, E. Trinka   +7 more
semanticscholar   +1 more source

Steps to prevent SUDEP: the validity of risk factors in the SUDEP and seizure safety checklist: a case control study [PDF]

Journal of Neurology, 2016
Our objectives were to compare people with epilepsy (PWE) who died of sudden unexpected death in epilepsy (SUDEP) with live controls using the risk factor items of the SUDEP and Seizure Safety Checklist. All 48 SUDEPs of 93 epilepsy deaths which occurred in Cornwall UK 2004-2012 were compared to 220 live controls using the SUDEP and Seizure Safety ...
Shankar, R, Walker, M, McLean, B, Laugharne, R, Ferrand, F, Hanna, J, Newman, C   +6 more
openaire   +4 more sources

Autonomic biosignals, seizure detection, and forecasting

Epilepsia, EarlyView.
Abstract Wearable devices have attracted significant attention in epilepsy research in recent years for their potential to enhance patient care through improved seizure monitoring and forecasting. This narrative review presents a detailed overview of the current clinical state of the art while addressing how devices that assess autonomic nervous system
Gadi Miron, Mustafa Halimeh, Jesper Jeppesen, Tobias Loddenkemper, Christian Meisel   +4 more
wiley   +1 more source

Combined analysis of risk factors for SUDEP [PDF]

Epilepsia, 2011
To pool data from four published case-control studies of sudden unexpected death in epilepsy (SUDEP) with live controls, to increase the power to determine risk factors.Case-control studies from the United States, Sweden, Scotland, and England were combined.
Thaddeus S. Walczak, Josemir W. Sander, Y. Langan, Emma K. T. Benn, Lena Nilsson, Martin J. Brodie, Ettore Beghi, Dale C. Hesdorffer, Torbjörn Tomson, Allen Hauser   +9 more
openaire   +3 more sources

Users´ perspectives and preferences on using wearables in epilepsy: A critical review

Epilepsia, EarlyView.
Abstract Seizure detection devices (SDDs) offer promising technological advancements in epilepsy management, providing real‐time seizure monitoring and alerts for patients and caregivers. This critical review explores user perspectives and experiences with SDDs to better understand factors influencing their adoption and sustained use.
Levente Hadady, Torie Robinson, Elisa Bruno, Mark P. Richardson, Sándor Beniczky   +4 more
wiley   +1 more source

Unique features of seizure‐induced cardiorespiratory failure in SSKcnj16−/− rats: Implications for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure‐induced disruption of vital physiological systems. The objective of this study was to characterize seizure‐induced physiological dysfunction leading to death in SSKcnj16−/− rats and ...
Melissa Eilbes, Alexander Gallo, Wasif A. Osmani, Paloma Bittencourt‐Silva, Anna D. Manis, Matthew R. Hodges   +5 more
wiley   +1 more source

Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases

Epilepsia, EarlyView.
Abstract Objective We retrospectively investigated a cohort of patients with ring chromosome 20 syndrome (r20), aiming to provide information on the prognosis of r20 regarding seizures, cognitive function, comorbidities, and social living. Methods Patients diagnosed with r20 in our hospital were identified, and clinical data were extracted from medical
Kentaro Tokumoto, Takuji Nishida, Hitoshi Ikeda, Hiroko Ikeda, Norihiko Kawaguchi, Satoshi Mizutani, Tokito Yamaguchi, Hideyuki Ohtani, Etsuko Yamazaki, Naotaka Usui, Katsumi Imai, Yushi Inoue   +11 more
wiley   +1 more source

Reduction of generalized tonic–clonic seizures following vagus nerve stimulation therapy: CORE‐VNS Study 24‐month follow‐up

Epilepsia, EarlyView.
Abstract Objective Generalized tonic–clonic seizures (GTCS) are considered to be among the most devastating seizures due to increased health risks. Use of device‐based therapies, such as vagus nerve stimulation (VNS), is common for those resistant to antiseizure medications and important for those in whom resective surgery is not feasible.
Ana Suller Marti, Ryan Verner, Mark Keezer, Andrea Andrade, Martin Veilleux, Kenneth Myers, Gaia Giannicola, Kathryn Nichol, Jorge G. Burneo, on behalf of the CORE‐VNS Registry Group   +9 more
wiley   +1 more source