Results 51 to 60 of about 2,407,462 (283)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Reconstruction of Christian Theodicy in Taras Shevchenko’s Poetry
Kyiv-Mohyla Humanities Journal, 2019 This article focuses on the role of Christian theodicy in Taras Shevchenko’s works. With a biography marked by trauma and suffering, it is no wonder that Shevchenko orients his poetic worldview in search of understanding the nature of evil and human ...
Olha Bihun
doaj +1 more source
Religions, 2021 This article argues that a compelling way to address the presence of suffering and death across evolutionary history lies in the thought of Joseph Ratzinger/Pope Benedict XVI.
Matthew J. Ramage
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
First, do no harm: The patient's experience of avoidable suffering as harm
Patient Experience Journal, 2018 Although my entire career has been spent in Patient Experience, nothing I have learned from data, evidence-based practice, or experience-based correlations, has been near as impactful as what I learned from being a patient.
Ashley Bauer
doaj
Superintelligence as a Cause or Cure for Risks of Astronomical Suffering [PDF]
, 2017 Discussions about the possible consequences of creating superintelligence have included the possibility of existential risk, often understood mainly as the risk of human extinction. We argue that suffering risks (s-risks) , where an adverse outcome would
Gloor, Lukas, Sotala, Kaj
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Prevalence and characteristics of tinnitus after leisure noise exposure in young adults [PDF]
, 2014 The main goal of this study was to assess the prevalence and characteristics of tinnitus among students after exposure to leisure noise. In addition, the effects of tinnitus on otoacoustic emissions (OAEs) in participants suffering from chronic tinnitus ...
Corthals, Paul +3 more
core +3 more sources