Results 61 to 70 of about 2,426,055 (315)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Relations and Moral Obligations towards Other Animals

open access: yesRelations, 2015
Relational accounts acknowledge and emphasise the intersubjective nature of selfhood and argue that focusing solely on the capacities of animals cannot account for all moral obligations towards them.
Beril Sözmen
doaj   +1 more source

Prevalence and characteristics of tinnitus after leisure noise exposure in young adults [PDF]

open access: yes, 2014
The main goal of this study was to assess the prevalence and characteristics of tinnitus among students after exposure to leisure noise. In addition, the effects of tinnitus on otoacoustic emissions (OAEs) in participants suffering from chronic tinnitus ...
Corthals, Paul   +3 more
core   +3 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V)

open access: yesClassica Cracoviensia, 2018
Erinys’ Mortal Venom: The Poetic Expression of Emotions in Silius Italicus’ "Punica" (Books I–V) Negative emotions are used to construct and develop the plot in the first five books of Silius Italicus’ Punica. Dark, irrational forces, i.e.
Stanisław Śnieżewski
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Illness and the Politics of Social Suffering: Towards a Critical Research Agenda in Health and Science Studies

open access: yesRevista Crítica de Ciências Sociais, 2018
This article analyses some of the emerging problems in the field of social studies at the juncture of the domains of health and science. Building on critical perspectives, namely those hailing from social history, postcolonial studies and collaborative ...
Tiago Pires Marques
doaj   +1 more source

Enough Suffering: Thoughts on Suffering and Virtue [PDF]

open access: yesThe Journal of Value Inquiry, 2021
Coplan, Amy, Battaly, Heather
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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